GCBA Seminar Series announces Steven Henikoff, PhD, Fred Hutchinson Cancer Center, Basic Sciences Division presenting "Cancer from a Chromatin Perspective" UNMC Dept of Genetics, Cell Biology & Anatomy UNMC Bioinformatics & Systems Biology Zoom Seminar

Huge congratulations to Rahul Dogiparthi, a Bioinformatics and Systems Biology graduate student working in our lab at UNMC, for being selected by ASH to receive the ASH Graduate Hematology Award (AGHA)! Very proud #ASHAwards

interested in 3D genome organization and SMCs? We have some updates on our preprint from last year with some interesting information/figures: biorxiv.org/content/10.110…

🎬The Lee lab loved putting on our actor hats in this video about student research UMass Lowell Biology & Kennedy College of Sciences at UMass Lowell. 🎥 It was filmed & produced by UMass Lowell Digital Media students, and they sure made us & the science look fantastic! youtube.com/watch?v=4JUgyB…

Our lab, in collaboration with partners from Genentech, Sanofi, @gsk, Pfizer Inc., Wellcome Sanger Institute, and EMBL-EBI, has been awarded £2M by Open Targets to generate novel perturbation data across multiple disease models and develop large generative models to facilitate the discovery

Exciting news for UNMC Dept of Genetics, Cell Biology & Anatomy! A research team received a 5-year, $1.45M NIH grant to expand the pipeline of data scientists in bioinformatics. Learn more: unmc.edu/newsroom/2024/…

It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammoth that died in Siberia, 52,000 years ago. 🦣💨 Don’t miss our thread below! 🧵👇🏽

It’s finally out!! 🥳 Our paper on the recovery of ancient chromosomes and 3D genome structure of a 52,000 year-old woolly mammoth just got published by Cell 🦣🧊

So happy this is out! We were thrilled to be involved in such an amazing story. Go check our this thread and don't forget to watch the music video that goes with it!

There’s still time. Apply for our postdoc position and come help us do cool stuff in 3D chromatin. jrowleylab.com unmc.peopleadmin.com/postings/85487

Thanks Omaha World-Herald for highlighting our part in this “mammoth” study. There were so many people working on this, so go check out the findings from their contributions too!

I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.110… 1/

(1/n) From Viraat Goel @Irate_Physicist et al. collab w blobellab Leonid Mirny biorxiv.org/content/10.110… RCMC at the M-to-G1 transition reveals strong microcompartments between CREs (E,P) in mitosis, that weaken upon G1 entry Sims reveal chromosome compaction as key regulator

📢It's a big milestone for the Lee lab - our very first preprint!!! 🥳 Grad student Deepshi A led a team of undergrads to ask how germ cells handle DNA damage with nucleosomes crowding the way 🚨 hint: 🚧NuRD remodeling clears a path for DSB repair🚧 biorxiv.org/content/10.110…

Congrats to Hannah for defending her dissertation early this week! So very proud of the first to defend from my lab!

Genome-wide analyses correlate nuclear speckle proximity with gene expression. We share our minireview discussing possible functional relationships between nuclear speckles and gene expression in both health and disease: authors.elsevier.com/sd/article/S09…

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

It’s a bit belated, but I am happy to share the latest work from our group, led by a very talented post doc in the lab, Tessa Popay Tessa Popay with great support from the 4D Nucleome consortium, Rita Allen, and the Pew Biomedical Scholars. biorxiv.org/content/10.110…