What is the long-term benefit of luspatercept in the treatment of anemia for transfusion-dependent patients with ring sideroblast-positive, lower-risk myelodysplastic syndromes who are erythropoietin-stimulating agent refractory/intolerant? Read our summary of a long-term

CONGRESS #ASH23 | Guillermo Garcia-Manero presented results from the phase III COMMANDS trial of Luspatercept Versus Epoetin Alfa in ESA-Naive pts with low-risk #MDS. 2.7% and 3.3% of pts in the luspatercept and epoetin alfa arms, respectively, progressed to #AML. With

CONGRESS #ASH23 | Rami S. Komrokji discussed results from the Imerge phase III study evaluating the efficacy of imetelstat across different IPSS risk categories. The TI rate for all IPSS risk groups at ≥1-year were 12.5% vs 2.6% for imetelstat vs placebo in the low risk pts and

CONGRESS #ASH23 | Moshe Mittelman presented results from MATTERHORN, an ongoing, double-blind, Phase III trial of roxadustat for treatment of anemia in pts with low-risk #MDS. At week 28 more pts in the roxadustat arm compared with the placebo arm were TI responders (47.5% vs.

CONGRESS | #ASH23 Caspian Oliai . UCLA Health discusses ph1b trial of Orca-T. 1-yr RFS was similar between patients aged 18-55yrs (n=38) and those >55 yrs old (n=25); 1-yr NRM=0% in both groups; 1-yr OS=100% and 96%. Donor chimerism at 3mo >90% in all ages. 1 case of

Elisabetta Sauta Leukemia Irst-Irccs Istituto Tumori della Romagna summarizes the significant contribution of transcriptomic features (40%), plus somatic gene mutations and cytogenetic lesions (24%), demographics (20%) and clinical features (15%) to survival prediction, in an integrative analysis of 389 patients with

CONGRESS | #ASH23 Eshana Shah Yale School of Medicine presents a mixed methods approach to understanding individual-level social determinants of health (SDOH) in 52 patients with #AML, HR #MDS or #ALL, and explains that age (>65yrs), financial toxicity and lower health literacy, but not PHQ-4,

CONGRESS | #ASH23 Rami Komrokji Rami komrokji Moffitt Cancer Center presents a mutational burden analysis from the COMMANDS trial. ▪️Luspatercept showed broad activity across MDS-associated mutations, including difficult-to-treat ASXL1 ▪️Response rates increased with luspatercept vs

CONGRESS | #ASH23 Valeria Santini Valeria Santini Università di Firenze presents long-term 26 month follow-up of patients with LR #MDS intolerant/ineligible for ESAs in the MEDALIST trial. ▪️Uninterrupted RBC-TI ≥1 yr was achieved by 41.3% of patients who achieved RBC-TI ≥8 wks, and

CONGRESS | #ASH23 Esther Natalie Oliva Grande Ospedale Metropolitano di Reggio Calabria presents an analysis of patient-reported outcomes in patients in the COMMANDS trial. ▪️Good side effect tolerability in both luspatercept and epoetin alfa arms (FACT-An item GP5) ▪️Improved times to sustained improvement to 24 weeks

CONGRESS | #ASH23 Valeria Santini Università di Firenze Imetelstat was superior to placebo in inducing ≥8wk & ≥24 week RBC-TI, regardless of number of baseline mutations ▪️Improved RBC-TI response to imetelstat vs placebo particularly noted in patients with SF3B1 mutations (≥8wk

CONGRESS | #ASH23 Enrico Attardi Enrico Attardi Università di Roma Tor Vergata St. Jude dissects ICC “diagnostic qualifiers”, using a cohort of 155 patients with #AML progressing from #MDS or MDS/MPN (sAML) and 65 patients with tAML, and comparing to 233 patients with de novo MDS-related AML

CONGRESS | #ASH23 Uwe Platzbecker Uwe Platzbecker UNIVERSITÄT LEIPZIG presents from IMerge ph3 trial of imetelstat vs placebo in patients with non-del(5q) LR-#MDS R/R or ineligible for ESAs. ▪️Of 33 patients who achieved ≥24-wk RBC-TI with imetelstat, 63.6% maintained for ≥1-yr;

How can clinical trial design in myelodysplastic syndromes be improved with clinically meaningful endpoints? 🔎 Read our latest article to find out! 👇 loom.ly/n5NoVvs #MDS #MDSsm

📺 Dive into expert insights on managing lower-risk MDS with signs of erythropoiesis-stimulating agent failure in our latest steering committee meeting video. Join Theo de Witte as he shares treatment strategies. A must-watch! 👉 loom.ly/srZrpcQ #MDSsm

🎬 Discover the latest insights on MDS classification systems! Join Pierre Fenaux as he delves into his updated approach in our new video. Don't miss this pivotal discussion from our MDS Hub Steering Committee meeting. 👉 loom.ly/Setfq8s #MDS #MedicalScience

A big thank you to our funders, who make it possible for us to deliver the MDS Hub Bristol Myers Squibb ThermoFisher Scientific Astex All content is developed independently by SES in collaboration with an expert steering committee; funders are allowed no direct influence on the

Want to find out how the IPSS-R and IPSS-M stratification systems for MDS compare? Find out in our editorial theme article outlining the development of these systems and their pros and cons. 👉 loom.ly/l7pFhKk #MDS #leusm

🚨NEWS 🚨 First patient dosed in the phase II BEXMAB trial, evaluating bexmarilimab, an anti-Clever-1 humanized monoclonal antibody, in combination with standard of care in patients with R/R MDS previously treated with HMAs. loom.ly/STJGPwE #MedNews #leusm

Has the IPSS-M model changed the extent of the molecular testing you perform for patients with MDS?