Super interesting study! Congratulations Eugene Gardner Matthew Neville Matt Hurles & team
An unexpected observation to a fascinating science story where we got to cite Darwin.
Great learning experience as a new PhD student to see the serendipity of a project’s origins but also the immense effort by Eugene Gardner & all others involved to deliver the final product!
Finally, a big thank you to everyone that contributed to this work! Raheleh Rahbari Rashesh Sanghvi Matthew Neville Petr Danecek Patrick Short Loukas Moutsianas Chris Odhams Helen Firth
Network for Young Researchers in Andrology Sandra Laurentino @sandralaurentino.bsky.social Raheleh Rahbari Rod Mitchell Kristian Almstrup Antoine Molaro Simone Immler Gülizar Saritas Oguzhan Kalyon Criss Sylwia Lustofin Emily.delgouffe Matthew Neville Shruti Avinash Aarveti It was an absolute pleasure! A huge thanks to everyone !!!
@luiza_moore Mathijs Sanders Alex Cagan Tim Coorens Rashesh Sanghvi Matthew Neville Inigo Martincorena Heer Lab Rebecca Fitzgerald Lab Raheleh Rahbari Nice work Luiza, congrats!
Matthew Hahn Yeah, that would be my understanding - seems like most (almost all?) mutations would've already happened
This started as a rotation project led by the amazing Sanger PhD student Matthew Neville supervised by Kaitlin Samocha, myself and our PI Matt Hurles. Following some cool initial findings, it 'evolved' into what you see today.
@luiza_moore Mathijs Sanders Alex Cagan Tim Coorens Rashesh Sanghvi Matthew Neville Inigo Martincorena Heer Lab Rebecca Fitzgerald Lab Raheleh Rahbari Congratulations @luiza_moore and coworkers! Fantastic work!
Aylwyn Scally HwangSeongwon Matthew Neville Genomics England Very interesting thread. Given paternal age affects mutation spectrum as well as rate is it possible to estimate average paternal age over human evolutionary history through extant neutral polymorphisms?
Joanna Kaplanis Raheleh Rahbari Rashesh Sanghvi Matthew Neville Petr Danecek Patrick Short Loukas Moutsianas Chris Odhams Helen Firth Great to see this out! Many congratulations Joanna, Matt Hurles and team, amazing work
Shout out to our amazing invited speakers Sandra Laurentino @sandralaurentino.bsky.social Raheleh Rahbari Rod Mitchell Kristian Almstrup Antoine Molaro Simone Immler. Was a blast to have you here Gülizar Saritas Oguzhan Kalyon Criss afsanehkhoshkerdar Sylwia Lustofin Emily.delgouffe Matthew Neville Shruti Avinash Aarveti
Congratulations & thanks to the first co-authors Thomas Oliver, Lia Chappell and all the co-authors Rashesh Sanghvi Matthew Neville Tim Butler Tim Coorens Naser Ansari-Pour Matthew Young Stefan Dentro Mathijs Sanders Alex Cagan Tom Mitchell Isidro Cortes-Ciriano [8/10]
Aylwyn Scally HwangSeongwon Matthew Neville Genomics England Hi Alwyn, amazing paper and great to see data from this project used. 1) are these rare disease individuals? 2) what is the overall h2g of the trait? 3) what’s the std errors around the h2g estimates? 4) excited to see non pca subset spectra data!
This endeavour is a collaborative effort across great teams with diverse expertise! Well done to @luiza_moore @Alex_cagan and @Tim_coorens who are the main drives of these studies. Please do check their amazing tweetorials!well done Rashesh Sanghvi Matthew Neville Mathijs Sanders
Jyoti Nangalia Mathijs Sanders Alex Cagan Tim Coorens Rashesh Sanghvi Matthew Neville Inigo Martincorena Heer Lab Rebecca Fitzgerald Lab Raheleh Rahbari Great help from Ayesha Noorani from Rebecca Fitzgerald Lab Tom Mitchell and Mabel Teng!
Joanna Kaplanis Raheleh Rahbari Rashesh Sanghvi Matthew Neville Petr Danecek Patrick Short Loukas Moutsianas Chris Odhams Helen Firth Amazing, Joanna! Congrats, and great thread! 🥳🎉