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How do you make the impossible possible? Our latest research article: "Seven (.65) Seconds Away: The Possibility and Physiology of a Women's Sub-4 Minute Mile." doi.org/10.1152/japplp… Faith Kipyegon will make her attempt at the Stade Charlety in Paris, on June 26.

Does #antioxidant supplementation influence the outcomes of #SIT #training? #skeletalmuscle fans, we might have some information for you. #proteomics leads the way! doi.org/10.1113/JP2886… Kudos to the great Håkan Westerblad and to the whole amazing team.

Our latest ME/CFS paper examines the content of extracellular vesicles in male ME patients vs controls before and after exercise. Among pathways implicated are the TCA cycle, complement system, protein folding, ER stress tinyurl.com/266nsx9a

Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activates hepatic gluconeogenesis Molecular Metabolism sciencedirect.com/science/articl…

New study where we investigate whether 1) ‘super shoes’ work for recreat. runners, and 2) why some runners benefit more 1. Super shoes improved RE by 2–4% 2. Comfort, anthropometrics, muscle architecture & running style didn't explain who benefited most onlinelibrary.wiley.com/doi/10.1111/sm…

Recent #Research by Maria Hansen (University of Copenhagen Research) et al. finds that the skeletal muscle response to high-intensity training assessed by single-nucleus RNA-sequencing is blunted in individuals with type 2 #diabetes 🚴‍♀️ 🧬 📜 Available here: buff.ly/BGV22da

SAMP-Score: A morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells biorxiv.org/content/10.110… #biorxiv_cancer

Pleased to see our latest pre-print out on BioRxiv. Use of phenotypic screening and machine learning for drug discovery in senescence marker-positive breast cancer Cleo Bishop Lab

Organ-specific isolation of hepatocyte extracellular vesicles from human plasma enables tissue-resolved proteomic and miRNA profiling biorxiv.org/content/10.110… #biorxiv_molbio

🧬 new study in Cell has demonstrated that transplantation of engineered senescence (seno)-resistant human mesenchymal progenitor cells (SRCs) can significantly slow or even reverse biological aging across multiple organ systems in non-human primates. linkedin.com/posts/lfontana…

A study in Nature Neuroscience reveals the molecular mediators that underlie exercise’s protective effects in Alzheimer’s disease. go.nature.com/4l6fdfQ

this summer NewLimit, we built our first prototype medicine that restores multiple youthful functions in old hepatocytes. rejuvenating old cells across multiple dimensions seems more possible today than just months ago. recent highlights - +3 TF sets that restore function in

Dietary gamma-aminobutyric acid enhances endurance exercise capacity through mechanisms involving activation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha sciencedirect.com/science/articl…

🔔 Come and join out team 🔔 We're looking to hire a post-doc (full time 29 month position) for an exciting new project funded by Alzheimer's Research UK 🔗: jobs.ncl.ac.uk/job/Newcastle-…

#Exercise continues to be the best medicine. A personalized exercise therapy and self-management support program is more effective than usual care alone in improving health-related quality of life at 12 months in adults with multimorbidity @naturemedicine nature.com/articles/s4159…

Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle nature.com/articles/s4146…

Pancreatic Cancer-Derived Extracellular Vesicles Enriched with miR-223-5p Promote Skeletal Muscle Wasting Associated with Cachexia advanced.onlinelibrary.wiley.com/doi/10.1002/ad…

science.org/doi/10.1126/sc…

DNA methylation protects cancer cells against senescence nature.com/articles/s4146…

Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response sciencedirect.com/science/articl…