Rac2 constitutive activation : from sensing bacterial virulence to severe combined immunodeficiency Congrats Laurent Boyer and the team for this exciting story 🎉🥳

#WeekendRead! #ImmunometabolismPower! Brendon Chua, Katherine Kedzierska, Wang, Jia, Crawford &co show Cell that in macrophages oleic acid inhibits IFITM3 & drives excessive #inflammation upon fatal avian & seasonal #influenza, #COVID19, #MISC & #RSV! doi.org/10.1016/j.cell…

Just arrived at #ECI2024. Stop me of you want to chat some science. We also have open positions with exciting T-cell projects!

One day left before the Cytokine Bracket semi-finals! polltab.com/bracket-poll/n…

It was great to work with Si Ming Man on this review for Nature Cell Biology to discuss how dying #cells are sensed and the physiological impact of how cells die. Significant implications across the #disease spectrum. Check it out! St. Jude Research

#CoagulationPower! Stark &co show Immunity that antigen-independent activities of antibodies drive pathological coagulation! IgM activate endothelial cells that recruit platelets that bind IgG inducing #complement activation, NETosis & thrombosis dlvr.it/TCk6g5

Semi-finals of Cytokine Bracket are LIVE! It's IL-1alpha/beta vs. IL-4 and IL-17 vs. IFNlambda. Great representation of distinct cytokine families, innate & adaptive immunity. Voting open for 2 wks - no signup needed, vote 1x per device. International Cytokine & Interferon Society (ICIS) polltab.com/bracket-poll/n…

🚨 TWITTER!! 🚨 Our Dept is recruiting junior faculty! Please RT and share in your circles 🙏🏼😊 This is a broad search in GI patho/physiology. But, pancreatic cancer researches, do take note! Contact Shah Lab or Lyssiotis Lab with questions 🤝

We are hiring HSCRB!! If you’re interested in applying, come to our info session 9/23 at 1pm ET! This is a great place to grow your research program!

#ImmuneScar! Reddy Zhao &co show Cell Stem Cell that during graft-vs-host disease, intestinal stem cells #ISCs are scarred by inflammation! They accumulate succinate, that alters DNA methylation, persistently decreasing their proliferation & differentiation dlvr.it/TCmw37

New paper out nature - why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? sex chromosomes or hormones? Here we studied adaptation of human immune systems to gender-affirming

In our new paper out today nature.com/articles/s4158…, we started with a simple hypothesis - inspired by work on IL-4/IL-13 from Brian S. Kim - that an innate immune cell might control sensory neuronal detection of allergens via a secreted factor. (1/11)

#EveryCellIsAnImmuneCell! Jie Sun Harish Narasimhan Wei Qian Peter Chen Chongzhi Zang &co show nature that long-term viral lung sequelae are driven by CD8Tcell IFNg & TNF that drive IL1b by macrophages inducing dysplastic epithelial progenitors & fibrosis nature.com/articles/s4158…

Why do we itch? Ask your immune system, and Dr. Sokol and colleagues. They provide a simple and elegant answer to this timeless question. Kudos to the authors on this fascinating discovery. nature.com/articles/s4158… Caroline Sokol MDPhD Harvard Medical School

Immune landscape of oncohistone-mutant gliomas reveals diverse myeloid populations and tumor-promoting function. So excited to see this finally out. Amazing effort by Nada Jabado’s team and collaborators. One step closer to understanding gliomas. Congrats nature.com/articles/s4146…

Ready to start or move your lab? Chicago is a wonderful place to live and University of Illinois Chicago is a great place to work! Apply for our open faculty position in Microbiology and Immunology! uic.csod.com/ux/ats/careers…

🚨UVa Neurodegeneration job alert!! UVa Neuroscience is hiring multiple TT faculty in neurodegenerative disease research. If you're looking for a vibrant scientific community with wonderful colleagues then check it out! Please share/rt! UVA Research BIG_UVA UVA Neurology

We’ve just finalized the program for our EMBO Inflammasome Workshop. 🙌 Next to many amazing short talks, we have an incredible lineup of poster presentations featuring lots of unpublished work. Check out the full agenda on our website—there’s still time to register! 👇

💥Last day💥 for early bird registration to #MucosalImmunology2024! JOIN US: Jie Sun, Dr. Shruti Naik, Jose Ordovas-Montanes, Smita Gopinath, Megan Orzalli & Gretchen Diehl; Scott Snapper; Carolyn Coyne! Register & submit your abstract here 👉bit.ly/3RpweoY

#ItIsAKindOfMagic! Zihao Ou HongLab Mark Brongersma &co show Science Magazine that tissue transparency can be achieved in live animals utilizing a common food dye, allowing the “visualization of (…) deep-seated structures and activities”! science.org/doi/10.1126/sc…