Bill Wimsatt@fPET:”all interesting mechanisms are made of differentiated parts.”

See recent preprint under review on disease mechanisms: Preprint server for biology: bioRxiv doi.org/10.1101/350371 Harnessing formal concepts of biological mechanism to analyze human disease Lindley Darden, Kunal Kundu, Lipika Ray Pal, John Moult doi: doi.org/10.1101/350371

#ismb18 #MecCog poster for disease mechanism schemas

#PSA2018 Lindley Darden poster 47 on disease mechanisms

#PSA2018 Eric Saidel on chimps & seeing

Our PLoS paper is now available: Darden L, Kundu K, Pal LR, Moult J (2018) Harnessing formal concepts of biological mechanism to analyze human disease. PLoS Comput Biol 14(12): e1006540. doi.org/10.1371/journa… Pub: December 26, 2018; Check out meccog.org

I’m attending the SURe (Scientific Understanding & Representation) Workshop by ZOOM. Working pretty well. I’m pushing: diagrammatic representation of disease mechanisms provides understanding.

Congrats to my grad advisee who just published this paper: Kalewold, K.H. (2002), “Race and Medicine in Light of the New Mechanistic Philosophy of Science,” Biology & Philosophy 35: 41. Published on line 9 July 2020: doi.org/10.1007/s10539…

Attending the Advances in Cognitive Systems 2020 virtually this year

Our latest paper is now available as a preprint:

Why don’t philosophers use slides??? #PSAonCOVID

My MecCog collaborator John Moult is interviewed in this video: Deep Mind's success on protein folding. youtu.be/gg7WjuFs8F4 Next step: discover the mechanisms in which the proteins act.

Glad to see all the work in mechanistic models by philosophers is science #PSAPosters

Our latest paper has just been published: MecCog: A knowledge representation framework for genetic disease mechanism Kunal Kundu, Lindley Darden, John Moult Bioinformatics, btab432, doi.org/10.1093/bioinf… Published: 12 June 2021

Informative interview with John Moult about AlphaFold & our MecCog framework for genetic disease mechanisms: “A Deep Dive Into Modeling and Mechanisms”: escholarship.org/uc/item/1vw1g3…

#APOE23 My collaborator John Moult is on his way to St.Louis for APOE conference with our poster: Critical Assessment of Disease Mechanisms. I’ll follow virtually.

#apoe23 John Moult (of CASP fame) and I have a poster with 28 possible mechanisms for APOE4 at #apoe23 conference and a Discord server to critically assess relation to Alzheimer’s Disease. Join us.

#ISHPSSB2015: Learned a lot about ENCODE vs. junk DNA controversy: hinges on selected effect vs causal role functions; sorry to miss ISMB15

Sorry to miss #ISH17 beginning in Brazil. I'll be happy to see tweets about mechanism discussions.

Very crowded at National Book Festival: standing in line for 30 minutes trying to hear author on gene book😩☹️😔