Our paper is out! We directly show that TDP-43 build up in neurons of the motor cortex can drive a hyper excitability phenotype that propagates through the corticomotor system to cause lower motor neuron death. Critical proof of concept!! Funded by MND Research Australia and NHMRC

Tassie MND researchers join forces for #mndweek2023 and cake. Thanks Andrew Phipps for organising. Don't fear, my research skills are better than my cupcake skills.

Very happy to see our mini review out today in ⁦Frontiers⁩ in Neural Circuits! ⁦Written by SantiMora⁩ and myself 😎 doi.org/10.3389/fncir.…

Today I passed my first major milestone of my PhD 🎉 looking forward to the next 3 years! Many thanks to my wonderful supervisory team Catherine Blizzard 🌟 MND Research Australia

I'll be sharing our latest results tomorrow as part of the FightMND Scientific Seminar series. Register using the link: fightmnd.org.au/fightmnd-scien…

Our new Perspective on non-invasive brain stim (particularly rTMS) is out! Explore how recent research shows plasticity, network, and cell-type specific mechanisms & how to leverage animal studies to refine our understanding and application of rTMS/tES. journals.lww.com/nrronline/full…

If you'd like to hear about how rare genetic variants associated with MS can cause motor dysfunction and cellular changes within the brain, come by my talk this Wednesday!

NEW PAPER: We generated Oligodendroglial Progenitor Cells (OPCs) from hiPSCs harboring FUS mutations. Our results demonstrated the pathological role of mutant FUS in OPCs, highlighting the significance of glial cells in FUS-ALS. link.springer.com/article/10.100…

Excited to share our latest manuscript where we show static magnetic stimulation can drive structural AIS plasticity in inhibitory neurons in vitro. Alex Tang UWA Research Perron Institute nature.com/articles/s4159…

Big thanks to the team making this work possible where we used our biochem to diagnose a patient with a new SOD1 variant. Personally, my most meaningful work to date, helping a patient understand their condition. tandfonline.com/doi/full/10.10… Molecular Horizons @ UOW UOW Research

I am happy to share our latest review from the Brew Lab. A publication bringing together a large group of talented researchers! We explore the kynurenine pathway of tryptophan metabolism in stem cells. In health, disease, and stem cell therapeutics. doi.org/10.1177/117864…

Very excited to share our new pre-print using human iPSC-derived organoids containing extensive, mature myelin and functional microglia to model demyelination and oligodendrocyte/myelin regeneration #organoids #MS biorxiv.org/content/10.110…

So excited to start my post-doc in the Rothstein Lab!!

Great to see Tram's paper online showing that rTMS increased interneuron activity following demyelination and increased remyelination by new and surviving oligodendrocytes. Thanks to coauthors including Carlie L Cullen , Alastair Fortune , Laura Reale , Tom Lewis .

Delighted to share our paper on the influence of the #NodeOfRanvier on in vivo #axonaltransport of #mitochondria and #signallingendosomes iScience journal The MNP Lab @J_N_Slayer Samuele Negro. A project that started in 2018 but has finally seen the light of day!