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This is one of the coolest papers I've ever seen. Degranulating mast cells trap neutrophils inside them. After 12 hours, the neutrophils start to die and the MCs release their contents. Coined nexocytosis, this boosts MC fitness and increases the pro-inflammatory response. Crazy!

#LEMLab battled @DrElenaSF in the departmental bakeoff earlier this week. A fabulous spread of protease-themed delights: N-terminomics cake, fluorescence-guided surgery cupcakes, ABP tiramisu, ponceau-stained membranes, red bean rice nuclei, and pH-responsive dyes. What talent!

Excited to welcome Stephanie as a new graduate researcher in the #LEMLab. Thanks Anthony O'Donoghue for the recommendation 😀

We are hiring! Join Verdoes Lab at the LUMC Leiden Immunology department to apply chemistry to pioneer the next generation cancer vaccines: linkedin.com/posts/oncode-a…

Happy to share the latest from #LEMLab's Alex Ziegler and Beth Anderson in collab with Rocco Latorre, Nichollas Scott and Dufourlab. We show that legumain is activated during colitis and identify protease substrates in naive and inflamed colon. doi.org/10.1002/jcp.31…

Super proud of Francesca for delivering an excellent final presentation about her 3rd year project in the #LEMLab. Her actual N-terminomics data matched the quality of her cake! Quite a feat!

It's been a big week for this proud supervisor. I am so pleased to announce that Alex Ziegler has been awarded the Bill Sawyer Medal, which recognises outstanding achievements of Graduate Researchers in the Dept of Biochem & Pharm. Alex has had a great year and is so deserving!

I am happy to share a another manuscript by Bangyan Xu, a fun collaboration with Simon and Philip Thompson. We report some new sulfoxonium ylide activity-based probes for cysteine cathepsins. Check it out! pubs.acs.org/doi/10.1021/ac…

Prof. Matthew Boygo, expert in chemical proteomics, to give plenary talk at MCCB 2025! Don't miss this chance to learn from a visionary. 🔗 bit.ly/4hb6pEl #RACI #ozchem #BOD1640

We’re thrilled to welcome our 14th Snow Fellow, Dr Alisa Glukhova Alisa Glukhova, a structural biologist from WEHI (Walter and Eliza Hall Institute). Alisa’s work focusses on how cells communicate and what happens when those signals go wrong, leading to diseases like cancer. snowmedical.org.au

Incredibly excited to share Dr Alisa Glukhova has been awarded a prestigious Snow Medical Fellowship - the only recipient this year! She'll receive $8M over 8 years to advance her groundbreaking #cancer research. Congrats Alisa Glukhova #medicalresearch 🔗 wehi.edu.au/news/wehi-canc…

linkedin.com/posts/laura-ed…

Excited to share this story from my PhD, out today in Nature Communications. We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB. nature.com/articles/s4146…

We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS-independent manner. A wonderfully enjoyable collaboration with Laura Edgington-Mitchell & Hayley Newton labs (with significant mass spec guidance from Nichollas Scott!) Doherty Institute UniMelb MDHS

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by U.S. FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,

The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below. 1/3

#News: Phase 2B VISUALIZE study results will be presented by Penn Medicine’s Dr. Sunil Singhal at #ASCO25, demonstrating that intraoperative molecular imaging with abenacianine for injection (VGT-309) during lung surgery has the potential to improve surgical outcomes. More: