Finally online! Efficient HDR in plants by engineered CRISPR-endonucleases! Big Thanks to all involved! 🎉 doi.org/10.1016/j.molp…

This is just eukaryotes, btw. Prokarya likely uncountable. There is so much left to be discovered and so much literally anyone can contribute to. The living world awaits description. Get out there!

Celebration time 🎉Excited to announce that my grant „Manipulation of protein translation as a virulence strategy of pathogenic bacteria“ with > 0.5 M € (Boehringer Ingelheim Foundation/BIS) got funded 🥂Thanks Manuel GF who inspired me for this with his fantastic work! (1/2)

Very excited to share our latest #preprint : "A RALF-Brassinosteroid morpho-signaling circuit regulates Arabidopsis hypocotyl cell shape", now available at #bioRxiv #Feronia #Brassinosteroid #Signaling #MorphographX biorxiv.org/content/10.110…

Our paper "ER-anchored protein sorting controls the fate of two proteasome activators for intracellular organelle communication during proteotoxic stress" is 𝙪𝙣𝙙𝙚𝙧 𝙧𝙚𝙫𝙞𝙚𝙬 now! have a look at the latest version of our ms here: biorxiv.org/content/10.110… #proteostasis

Job alert‼️We are searching for a #postdoc to study the "Manipulation of protein translation by bacteria". If you're interested in #proteostasis, processing bodies, TOR, condensates & pathogens etc. apply ♻️ 🔬🦠 Please share 📢 More info here and below theustunlab.com/positions/

Check out our game, DEGRADATOR! 🎮 Designed to popularize and educate on the ubiquitin-proteasome system and PROTACs. Perfect for kids 12+ but not only 😉 Dive into 10 fun levels to explore protein degradation. Available on Google Play and degradator-game.com 🚀

📢 We have an open #PhD position available to study "Processing bodies as a target of pathogenic bacteria". If you're interested in #proteostasis, processing bodies, plant-microbe interactions apply ♻️🌱🦠🔬 Please share 📢 More info in the ad and here theustunlab.com

📢 P L E A S E spread the word‼️ Registration is open for The International Plant Proteostasis Conference, in VIENNA, 17-20 September, 2024: oeaw.ac.at/gmi/news-event… Great line up, exciting topics, and friendly meeting. Please register early. #ippc24

Vienna, the place to be this year for the #proteostasis meeting. Best community ever! Friendly, supportive and innovative! the entire #theustunlab will be there 😎

I need to try this out! Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting biorxiv.org/content/10.110…

Last call 📢 There is still some time left (deadline 17.06) to apply for the #PhD position in #theustunlab. More info below in the post or here: theustunlab.com/positions/

VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-branched ubiquitin chains: nature.com/articles/s4159…

Huge shoutout to Chris Lima's lab Memorial Sloan Kettering Cancer Center HHMI for capturing basically the entire ubiquitylation cascade via cryo-EM!!! Congratulations to this creative tour-de-force that follows ubiquitin's path towards a substrate. nature.com/articles/s4158…

The Role of the proteasomes in the disassembly of stress granules after heat stress #PPStasis Plant_Proteostasis cell.com/molecular-cell…

🆕 & 🆒#Preprint led by JC De la Concepción adressing a key #evocellbio question: How can individual subunits of multimeric protein complexes functionally diversify without compromising the ancestral complex? (Using plant #Exo70 & #exocyst as template) )biorxiv.org/content/10.110… 🧵

Online Now: RNA polymerases reshape chromatin architecture and couple transcription on individual fibers dlvr.it/TCQz2s

30 Essays to Make You Love Biology Day 25. "Is the cell really a machine?" by Daniel J. Nicholson Living cells are far more complex—and beautiful—than any machines made by human hands. In this, amongst my favorite essays of all time, a philosopher points to four areas of

🚨 New paper alert from @martenssascha!🚨 We explore how transmembrane cargo receptors initiate selective autophagy. Through biochemical reconstitutions, we discover a new autophagosome biogenesis pathway with implications for therapeutic interventions. biorxiv.org/content/10.110…

Gautier LANGIN from Ruhr-Universität Bochum presents insights from a Multi-Omics Analysis of 26S Proteasome Genes and their regulatory elements, uncovering complex evolutionary trajectories