➡️Join us at the next BCDI meeting on Monday Sept 11th at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions led by Michael J. Lee on cell death in response to transcription blockade and Oyler-Yaniv Lab on cell death in infections. More info: BostonCellDeath.org

Intriguingly, & consistent with the earlier work of Poltorak Lab (pnas.org/doi/10.1073/pn…), Jenna found that unlike in mouse macrophages, WT Yersinia fails to induce cell death in human IECs & macrophages, indicating that human cells are unable to undergo YopJ-mediated death. 4/n

➡️Join us at the next BCDI meeting on Monday Oct 2nd at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions with chendi on inducing apoptosis in NSCLC and nabel on identifying novel therapy targets in thymic epithelial tumors. More info: BostonCellDeath.org

Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave bit.ly/3ZEKoWc

Check out this piece by one of our PhD students Zoie Magri, PhD in the The Conversation U.S. ! Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave theconversation.com/cell-death-is-…

This symposium on #celldeath and survival will discuss exciting developments in this field including inflamed tissues and non-canonical #molecularpathways. Register for #Pathobiology2024 to attend this session! bit.ly/3TndnfK Penn Tufts University University of Notre Dame Yale School of Medicine

A recent preprint from the lab of @AndrewOberst demonstrates that neurons can repurpose death complex components to induce an anti-viral response to Zika! I’ve highlighted their work in my latest preLights post. Check it out! prelights.biologists.com/highlights/rip…

Neurons repurpose death complex components to induce an anti-viral response during Zika virus infection. In her first preLight, Zoie Magri, PhD covers recent work from the lab of @AndrewOberst. #preprint #preLight 👉 prelights.biologists.com/highlights/rip…

How does RIPK1 drive activation of caspase 8 in Yersinia infection?? Read our latest paper in Cell Reports to find out! Congrats to first author David Jetton TuftsGSBS cell.com/cell-reports/f…

We found CD14 can switch Fas signaling from pro-death to pro-inflammatory! Check out our recent work in Cell Reports to learn more. Congrats to first author Zoie Magri, PhD! cell.com/cell-reports/f…

It was an exciting August in the Poltorak Lab! #Twisters @TuftsGSBS Zoie Magri, PhD Cell Reports

An exciting Halloween week for the Poltorak lab! Two successful PhD defenses in one week! Congrats David Jetton and Zoie Magri, PhD ! Big thank you to outside examiners Michelle Kelliher and Ivan Zanoni for fabulous discussions! @TuftsGSBS

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper Cell with Achille Broggi! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n authors.elsevier.com/a/1k2OAL7PXqSL5

After reporting a role for T cell MyD88 during cardiac adaptation to stress Circulation Research & in melanoma The American Journal of Pathology, we now decipher a molecular mechanism👇. Thank U The Journal of Immunology Abe Bayer Poltorak Lab Zoie Magri, PhD Tufts School of Medicine academic.oup.com/jimmunol/advan…

Have you seen our papers on T-cell Myd88 in HF and cancer (links in 🧵) and wondered what the mechanism at the TCR was? We now outline a novel molecular role for MyD88 acting downstream of the TCR and regulating activation / cell death, out in The Journal of Immunology academic.oup.com/jimmunol/advan…

Thank you to Poltorak Lab Zoie Magri, PhD Pilar Alcaide, PhD for making this study possible. Previous papers on T-Myd88 at Circulation Research (ahajournals.org/doi/10.1161/CI…) and The American Journal of Pathology (sciencedirect.com/science/articl…)

Excited to have contributed to this paper!!! Read here how STING regulates microglia in aging. Congrats to Kate Sulka and the whole team!!! Cell Reports sciencedirect.com/science/articl…

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production Science Immunology Poltorak Lab science.org/doi/10.1126/sc…

#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show Science Immunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release science.org/doi/10.1126/sc…

Scientists have found that tumor necrosis factor can switch macrophage #efferocytosis from immunologically silent to pro-inflammatory during #sepsis and systemic inflammation. Poltorak Lab Learn more in Science #Immunology: scim.ag/45Yvj6Y