Check out our latest story on HPF1 regulation of PARP1/2!

Our new paper on PARP1/2 and HPF1 is out @Naturecommunications! HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications disq.us/t/42yjt6d

Happy to share our first Cryo-EM structure! Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase cell.com/structure/full…

We are excited to share our latest structural study on PARP1 mechanism of activation! Cheers to @IcrLordLab for a nice collaboration! AddThis | Home authors.elsevier.com/a/1fMUZ3vVUPK8…

Does distinct end of poly(ADP-ribose) matter? John Pascal Lab and our lab Morgan Dasovich Isabel Rose Uribe, PhD SJ CHENG found antiviral PARP13 binding to 2' end of PAR in an unexpected way. Excited to see our technology to label both PAR ends come to good use! cell.com/cell-reports/f…

We have a position open for a postdoctoral scientist. The projects in the lab focus on structural biology of ADP-ribosylation and drug discovery. #parp #fbmm #structuralbiology rekry.saima.fi/certiahome/ope…

Check our latest work on PARP2 and PARP inhibitors. Great collaboration with Zha Lab! Clinical PARP inhibitors allosterically induce PARP2 retention on DNA biorxiv.org/content/10.110…

New dropbox has been set up at the University of Montreal Université de Montréal in Montréal, QC! Pickups are Fridays at 2pm, located in Room 2057, Pavillon J.-Armand-Bombardier. Thanks to John M. Pascal for hosting this new box! 🥳🥳🥳

Our latest paper on PARP2 is now out! Thanks to Zha Lab for a very nice collaboration. Clinical PARP inhibitors allosterically induce PARP2 retention on DNA science.org/doi/10.1126/sc…

I’m extremely proud to share that my first first author paper was published today. Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP academic.oup.com/nar/article/do…

TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects! Post 1: DNA damage response my.corehr.com/pls/uoxrecruit…

Online Now: PARP enzyme de novo synthesis of protein-free poly(ADP-ribose) dlvr.it/TG7yqg