A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more: scim.ag/ME Roychoudhuri Lab Moraga Lab Suman MITRA Inserm Canther_Lille @CamPathology

Another straightforward reason why the Warburg metabolism causes immune suppression in the TME IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein science.org/doi/10.1126/sc…

A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more in Science Immunology: scim.ag/O8

A new study looks to make IL-2 therapy more effective in tumors, presenting a variant of the cytokine that retains its binding affinity in low pH environments. Read more in Science Immunology: scim.ag/R5

Today's #shoutout to #womeninSTEM goes to SILVIA GAGGERO for her Science Immunology paper w/ Suman MITRA showing IL-2 is inactivated by the acidic pH environment of #tumors enabling engineering of a pH-selective mutein. science.org/doi/10.1126/sc…

SPOTLIGHT: After showing that tumor-derived lactic acid limited IL-2 signaling, STAT5 phosphorylation, and antitumor activity in the TME, Inserm Suman MITRA used directed evolution to identify a pH-selective IL-2 mutein that bound IL-2Rα with [...] 👉 ow.ly/QAse50M3ptF

#Cancer L’acidité des tumeurs nuit à l’efficacité des thérapies anticancéreuses, selon une nouvelle étude. Des résultats qui pourraient conduire à une nouvelle génération de traitements d’immunothérapie. ➡️bit.ly/3hLyjNq

NEW for 2023 on the Science Immunology website is the dedicated CANCER IMMUNOLOGY block. 🔗➡️bit.ly/Cancer_Immuno Scroll down to it & check out 6 recent #cancerimmunology papers. More exciting new content is on the way to this space soon!

Going to AAI? Please join us for the ICIS Guest Symposium "Understanding and Modulating Cytokine Activity through Structural Knowledge" Juan L. Mendoza Saturday, May 13; 10:15 AM – 12:15 PM Eastern Time in Room 102AB cytokinesociety.org/understanding-… via @httpstwittercomCytokineSociety

Join us for the ICIS-sponsored and organized session at Immunity 2023! Learn how both academic and industry members of ICIS are advancing our understanding of cytokine biology and developing future immunotherapeutics.

Interested in interleukin-6 and how you can therapeutically block its pro-inflammatory activities? See our latest review, just published in Nature Rev Immunol — great team work together with Jenkins Lab, Stefan Rose-John Universität Kiel CAU 🎓 and Jens Moll/Jürgen Scheller Heinrich-Heine-Universität Düsseldorf

So excited for this session, I couldn’t sleep! Cytokines, engineering, structures, and therapies. Not a session to miss! 10:15 AM-12:15 PM room 102AB

📜State-of-the-Art📜 Molecular and cellular factors determining the functional pleiotropy of cytokines 🖋️ By Alison McFarlane, Elizabeth Pohler and Ignacio Moraga from University of Dundee 🔗 buff.ly/3pWOAme #cytokinesignalling #endosomessignalling

Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis biorxiv.org/cgi/content/sh… #bioRxiv

Ever wonder why ancestral cytokine receptors, like Gp130, bind multiple JAKs, and whether the identity of the GP130-JAK complex instructs specific responses? Check our new work, in a full collaboration with the PiehlerLab, for some answers biorxiv.org/cgi/content/sh…

🚨2 Yr Postdoc Available🚨 Jointly supervised with David Kent working on normal and pathological HSCs, cytokines, malignancy, clonal expansion. Come and join us at the newly-formed Centre for Blood Research York Biomedical Research Institute Apply here 👇👇👇jobs.york.ac.uk/vacancy/post-d… Pls retweet and DM!

#Cytokines2023 Metabollix and friends, thanks so much Luke O'Neill

Excited to share our newest full collaboration with Bubeck Lab. We provide structural insights that help explain how mutations in gp130 that do not disrupt cytokine binding cause signaling defects and immunodeficiencies in humans. doi.org/10.1038/s41467…, Cell Signal and Immunology, University of Dundee

Disease-associated variant in IL6ST gene encoding for gp130 led to increased flexibility including motion within the cytokine-binding core (IL-6 and IL-11) and increased distance between extracellular domains nature.com/articles/s4146…

After a hard year, I’m glad to see this finally over the line. A real team effort from ⁦Yibo Jin ⁦Scott Gardner⁩ ⁦Tomas Voisin and others from ⁦Moraga Lab. As always, amazing data collection support ⁦eBIC Beamline⁩ #cryoem ⁦ nature.com/articles/s4146…