#Bioinformatics #AI: researchers have developed a multiplex-heterogeneous network embedding framework to facilitate the analysis of complex interactions in dynamic networks. The framework could be used to predict gene-disease and drug-target interactions - nature.com/articles/s4159…

1/n Very excited to put this paper out in the world! Does reduction always lead to a gain in information? Turns out: no. Thomas F. Varley and I show macroscales can convert information (making info more synergistic), and reduction can lead to a loss of info arxiv.org/abs/2104.13368

One reason, btw, that I'm so excited about this paper is that I think it represents the most fundamental leap forward in my thinking about emergence and reduction since the "Quantifying causal emergence" paper in 2013

New preprint is up! arxiv.org/abs/2211.08522 Léo PioLopez, @JojoBischof, Jennifer V. LaPalme "The scaling of goals via homeostasis: an evolutionary simulation, experiment, and analysis" #Alife #BasalCognition #VirtualEmbryogeny I've been floating a theory of how homeostatic

Official version is out: frontiersin.org/articles/10.33… Léo PioLopez Franz Kuchling Giovanni Pezzulo Angela Tung "Active inference, morphogenesis, and computational psychiatry"

Next, in a series of preprints and papers getting over the finish line at end-of year: osf.io/7hxnp with Léo PioLopez: "Morphoceuticals: perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer, and aging"

Next up, Léo PioLopez and a remarkable finding about #aging. Preprint here: osf.io/preprints/osf/… Atavistic Genetic Expression Dissociation (AGED) during aging: meta-phylostratigraphic evidence of cellular- and tissue-levels phylogenetic dissociation Abstract: "Aging is

Official version of this paper with Léo PioLopez is out: link.springer.com/article/10.118… Universal multilayer network embedding bioinformatics method, and validation data in frog model (relevant to cancer)

Final version of this paper with Alexis Pietak is now out: sciencedirect.com/science/articl… "Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine" Abstract: gene regulatory networks (GRNs) are critically important for efforts in biomedicine and

New paper with hartl.bene : 'What does evolution make? Learning in living lineages and machines" cell.com/trends/genetic… Genes code for proteins, but what is the relationship between the genome and the large-scale form and function of organisms? What is a good formalism for

New #preprint - hartl.bene Léo PioLopez arxiv.org/abs/2509.11131 "Neural cellular automata: applications to biology and beyond classical AI"

Final version is out: aging as the result of loss of goal-directedness advanced.onlinelibrary.wiley.com/doi/epdf/10.10… hartl.bene Léo PioLopez "Although substantial advancements are made in manipulating lifespan in model organisms, the fundamental mechanisms driving aging remain elusive. No