Casali and colleagues describe a mouse model with a human lymphoid and myeloid immune system, that expresses BCR and TCR repertories as diverse as humans and mounts antibody responses to infection and vaccination. Read it here: rdcu.be/dLY2o nature.com/articles/s4159…

Research| Preece et al. demonstrate the suitability of naturally sterile Mus spretus hybrids for the generation of embryo transfer recipients, offering an alternative to surgically vasectomized males 🐭#3R The National Centre for the 3Rs Mary Lyon Centre at MRC Harwell The University of Manchester Centre for Human Genetics nature.com/articles/s4168…

#NewNProt: the OBSERVE guidelines enable the refinement of rodent cancer models by implementing optimal preparation and implantation methods, and monitoring adverse effects and clinical signs associated with organ-specific tumor development. rdcu.be/dNy6g

✨Our August issue is now live✨ nature.com/laban/volumes/… On the cover: New tool to efficiently monitor fibrosis-related changes in mice. Link 👉nature.com/articles/s4168…

New online | Tamoxifen is usually administered by gavage, which can be stressful. Thorsten Buch shows the use of a sweetened milk-based palatable tamoxifen formulation for effective and precise voluntary consumption, enhancing animal welfare. Link: 👇 nature.com/articles/s4168…

New online | Standardized zebrafish lab protocols are essential for replicable and reliable neurobehavioral research. Dr Matt Parker et al. comment on how water chemistry and environmental factors can impact behavioral outcomes. 🔬🐟 Link: 👇 nature.com/articles/s4168…

Correspondence | H. Kiaris discusses the paradox of "optimal conditions" in experimental biology. As ideal laboratory conditions don’t exist in nature, they can have unexpected implications for preclinical studies, such as drug development. Link: 👇 nature.com/articles/s4168…

Review │Fernandez et al. The National Institute on Aging (NIA) review state-of-the-art approaches (omics, deep phenotyping..) in preclinical #aging research, with a focus on rodent models. #tbt 🔙 #aging #ARDD2024 rdcu.be/dsljk

New online| Lab Animal spoke with Lydia Teboul and Guillaume Pavlovic to learn more about the Laboratory Animal Genetic Reporting (LAG-R) guidelines, designed to improve the reporting of genetic information for animal models Mary Lyon Centre at MRC Harwell IGBMC Our Q&A here: rdcu.be/dSnfp

Protocol| Sebastian Clauss and colleagues provide a practical guide to setting up pig models for cardiovascular catheterization, electrophysiological assessment and heart disease research (2022) #tbt 🔙 Link 👉 nature.com/articles/s4168…