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Excited to share our new single-cell GWAS method: scHi-HOST! Simultaneous genotype assignment, influenza quant, eQTL analysis from a single “pandemic-in-a-tube” assay. Discovered ERAP1 G346D associated with flu burden in cells and human challenge biorxiv.org/content/10.110…

Our latest preprint: human genetics meets nutritional immunity! Hi-HOST on 961 LCLs reveals MCOLN2 cation channel restricts Salmonella typhi replication by Mg2+ deprivation. 16 years in the making. Thanks Kyle D. Gibbs Liuyang Wang +team for getting us here biorxiv.org/content/10.110…

Curious about how cellular zinc (Zn) is trafficked to metalloproteins? New work from Eric Skaar and Giedroc Lab detailing the first Zn metallochaperone, ZNG1, published in Cell. Thread between me and co-first author Andy Weiss below. authors.elsevier.com/c/1f5G7L7PXioLf

Can DNA methylation regulate gene expression? Yes. But is m6A methylation a common generalizable mechanism of regulating gene expression in bacteria? Not for Salmonella under virulence conditions. Jury's still out for other bacteria; our latest shows how to test it systematically

Distilled my scientific worldview down to “The Awesome Power of Human Genetics of Infectious Disease”. So fun working on this accessible review in Annual Reviews with two incredible trainees Kyle D. Gibbs (now postdoc at Tufts) @BenjaminSchott_ annualreviews.org/doi/abs/10.114…

Registration for BBM2023 is now open! 🧪Abstracts submissions are due April 30th 🧫Online registration ends on May 31st You can register here: bostonbacterial.org/registration/

Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation dlvr.it/SlzYQz

Our latest cellular GWAS paper Cell Genomics reveals a cation channel (MCOLN2) serves as a critical restriction factor for replication of #Salmonella Typhi by Mg2+ deprivation. A thread that goes back 17 years (my youngest student was 7 years old!) 1/10 dlvr.it/SlzYQz