Excited to present the first paper from the Park group, published today in Science Magazine! We found a user-friendly, mild reaction conditions for exchanging an oxygen in heterocycles with nitrogen groups. Congrats Donghyeon, Jaehyun, and the team! science.org/doi/10.1126/sc…

First-in-human phase I/II clinical trial of STEAP1 CAR T cell therapy for mCRPC now open to enrollment! NCT06236139 PI: Jessica Hawley MD MS Fred Hutch Cancer Center #NExT Program @NCItreatment

Exciting: Phase I/II STEAP1 CAR T cell clinical trail for mCRPC! #CancerResearch #CART

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

Our paper on continuous mutagenesis in living cells using HACE is now out in Science Magazine! We now demonstrate that HACE continuously generates mutations over a 10-day period and enables targeting using dCas9 without introducing DNA nicks. science.org/doi/10.1126/sc…

Excited to share our recent manuscript out at nature . DanPiraner and Majo Duran from Roybal Lab and Mohamad Abedi and Adam Chazin-Gray in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. nature.com/articles/s4158…

[プレスリリース] 細胞外小胞の放出制御因子を網羅的に解析する方法を開発――CRISPR gRNAで「バーコード化」した細胞外小胞を活用して―――医学系研究科・医学部 u-tokyo.ac.jp/focus/ja/press…

Happy to announce that our “CIBER screening” paper describing the use of CRISPR-gRNA-barcoded extracellular vesicles (EVs) for high-throughput identification of EV release regulators is now out in Nature Communications! Congrats Koki Kunitake! nature.com/articles/s4146…

Excited to report that we have discovered a new, endogenous molecular clock in unmodified human cells and tissues. It is ticking away right now in almost every cell in your body. Specifically, in a new paper on BioRxiv, we show that RNA editing by the near-ubiquitous ADAR1 in

Terumi Tanaka, representative of 2024 peace laureate Nihon Hidankyo, gave a powerful speech today at the Nobel Peace Prize ceremony in Oslo. With stirring detail he recounted the events he witnessed on 9 August 1945 as a 13-year-old boy living 3 kilometers from the hypocenter of

Efficient non-viral immune cell engineering using circular single-stranded DNA-mediated genomic integration go.nature.com/3ZLpoPb

Please support this project by an Imperial College London scientist - if they get to 10,000 votes, it may get released by LEGO. Lego DNA 2.0: Double Helix History ideas.lego.com/s/p:c92cd95b49…

Congratulations to Rumya Mirco J. Friedrich Daniel Strebinger Blake Lash Cyrus Biotechnology and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and

nature.com/articles/s4158…

Nature research paper: Immune evasion through mitochondrial transfer in the tumour microenvironment go.nature.com/4g81Fhc

人間は過去も割と変えられる。最悪だった出来事が後から振り返ると人生で最高の転期だったってことはよくある。出来事は常に中立で、過去は現在の自分の状態に引きずられて意味が書き換わる。

Very excited and honored to visit The Francis Crick Institute to give the Crick Lecture and the 2025 Honess Lecture for Immunology this week on the "Immunology of Post-Acute Infection Syndrome"! crick.ac.uk/whats-on/crick…

Excited to share our new paper out in nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s4158…

Synthetic biology could enable new types of programmable therapeutics. Our new preprint introduces synthetic protein circuits that selectively trigger cell death in Ras-mutant cancer cells, with interesting advantages compared to existing approaches. biorxiv.org/content/10.110…

Proximity between LAG-3 and the T cell receptor guides suppression of ... sciencedirect.com/science/articl…