Would you be surprised to learn that acid chlorides are not only compatible with biological research, in water mind you, but are in fact, AMAZING? Read on to see the answer… 1/n

Please see the amazing work done by Xun Sun , published in Nat. Chem. today! Huge thanks to all of our great collaborators, Prof. Dr. Henning Mootz, Prof. Jhih-Wei Chu, Prof. Nozomi Ando (Ando Lab), and Prof. Tamiki Komatsuzaki (北海道大学)! nature.com/articles/s4155…

New issue! 📣 Read up on detection of RNA-protein interactions, selenoneine biosynthesis, riboswitches, sirtuins, functional amyloids, and more! pubs.acs.org/toc/bichaw/62/… #amyloid #RNA #biosynthesis

How to pick a problem. Today in Cell. 1/53 cell.com/cell/fulltext/…

What a great Take Your Child to Work Day here Princeton Chemistry with faculty, visitors, and kids enjoying crafts, lunch, and a campus-wide chem demo (thank you, PrincetonPhysics). Well done Sarah and Angie! #TYCTWD24

"Here, we describe our efforts to illuminate RNA biology through the application of chemical tools, focusing on post-transcriptional regulatory mechanisms." Enabling technologies from KleinerLab pubs.acs.org/doi/10.1021/ac… #tbt #ACSChemicalBiology #methods Princeton Chemistry

Ever wanted to incorporate ncAAs into your protein but found the efficiency to be too low? Check out our new preprint, where we turned a simple observation in protein translation to an effective quadruplet codon translation strategy!

We are just opening the summer Visiting Faculty Research Partnership season and are thrilled to be hosting, among others, the Graham Chakafana Lab of Hampton University. The lab will be doing malaria research hosted by the KleinerLab. This marks their 2nd summer Princeton Chemistry!

An honor to announce our book has been published! Many thanks to Martin Pettersson, the team at Wiley, and all our amazing contributors for making this exciting project happen! onlinelibrary.wiley.com/doi/book/10.10…

Congratulations to Qais Jaber, awarded a two-year EMBO Postdoctoral Fellowship supporting excellent postdoc research. Qais will continue his work in the KleinerLab deciphering RNA modifications in pathogenic bacteria.

The LSI at Princeton University invites applications for a tenure-track faculty position at the Assistant Professor level. We are seeking outstanding scientists in experimental genomics, systems biology, biophysics, or quantitative biology. Apply: princeton.edu/acad-positions…

Faculty & students from Emmanuel College, CSUSB and Hampton University spent the summer with Princeton Chemistry as part of the Visiting Faculty Research Partnership, working on projects that form the core of their research at home but with special focus at Frick: bit.ly/4edp5B8

We are looking for a postdoc candidate in RNA chemical biology, broadly defined. Interested applicants can email me at [email protected] with their CV, research summary, and names of 3 references. kleiner.princeton.edu

In lab's #FIRSTPREPRINT, we present methods to measure nanometer organization around & between specific proteins in condensates. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.

The final version of our protein transposition manuscript is now published in Science Magazine science.org/doi/10.1126/sc… We’ve added a few new things since our preprint /1

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity to find out - Biggest surprise was impact of encoded protein function. Fantastic work w/ Lindsay Becker Sofi Quinodoz David A Knowles (@davidaknowles.bsky.social) biorxiv.org/content/10.110…