Nausea and vomiting in pregnancy linked to hormone from fetus nature.com/articles/d4158… Thanks to Alice and Rachel for this very nice News and Views !

Congratulations Tom Powles on being featured in nature Nature’s10 2023 as the “Cancer Explorer” for your tremendous contribution to advancing #bladderca Tx #EV302! Uromigos The cancer physician who helped to deliver a life-extending treatment nature.com/articles/d4158…

A big day for bladder ca patients U.S. FDA. Massive team effort. Platinum based chemo superseded at last. EV/pembro will transform the lives of many pts with this difficult disease. Still lots to do but it’s a pretty good day and worth pausing for a moment. bit.ly/3GLntQn

When I thought I was done with the GWAS stories of 2023 and I should wrap up, stephen o'rahilly (its pronounced O-RA-hill-EEE) dropped yet another great paper from his team. How can I resist? It's storytelling time. In this hot-off-the-press Nature paper, Marlena Fejzo et al. uncover an absolutely fascinating

Well said. A Perverted View of “Impact” | #Science #sciencetwitter ⁦Science Magazine⁩ science.org/doi/10.1126/sc…

51 years in the making till #GU24. OS benefit in adjuvant Renal Cancer is finally here. #KYN564

Massive congrats to Sid – just published in Nature Genetics Our study defines a series of pathway-derived subtypes (PDS), which we use as the basis for identifying a previously overlooked phenotypic landscape in colorectal cancer… nature.com/articles/s4158… 🧵👇

Delighted to be a recipient of a grant from the Terri Brodeur Breast Cancer Foundation TBBCF, generously supporting my research into anti-NMDA receptor antibodies as a novel therapy for triple-negative breast cancer. tbbcf.org/tbbcf-names-20…

"Our Foundation asks a great deal of our awardees and their respective institutes. 100% of gross funds must go directly to activities focused on high-impact areas of clinical and preclinical breast cancer therapeutic research." tbbcf.org/tbbcf-names-20…

Glucocorticoids (GC), like dexamethasone and prednisolone, are widely used in medicine, but how do they actually work? This is really impressive work (Auger et al.), which figured it all out There are two mechanisms: a slow, broad response, which depends on transcriptional

Very happy to share our study published Journal of Clinical Oncology ! ascopubs.org/doi/full/10.12… ➡️Patients with mUC with NECTIN4 amplifications (occurring in app. 25%) show remarkable responses to single-agent EV, with a 96% objective response rate compared to 32% in non-amplified cases. NECTIN4

nature.com/articles/s4159… We are excited to share our latest research on the structural and functional mechanisms underlying anti-NMDAR encephalitis. Our study reveals that three antibodies, isolated from different patients, bind to distinct regions of the NMDARs 1/n)

Thrilled to share our paper now out nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by Andrew Moorman Ellie Benitez, and @f_cambuli from the Karuna Ganesh Lab and @dana_per lab! nature.com/articles/s4158… rdcu.be/dYAVK. A 🧵

A commonly inherited genetic variant of human PCSK9 drives breast cancer metastasis and associates with reduced patient survival. Cell PCSK9 drives pro-metastatic genes by repressing LRP1. Anti-PCSK9 antibody has breast CA metastasis suppressive effects

V pleased to share our paper on the immune landscape of CSF in MS and other conditions cell.com/cell-reports-m… now out in Cell Reports Medicine Fun and stimulating collaboration with co-first author Christiane Gasperi and senior authors Maria Ban, Steve Sawcer and Bernhard Hemmer

"Why do I no longer enjoy my favorite food and activities?" - an important question from our patients with cancer and cachexia! Cancer is a disease of the whole body, including the brain. Kepecs Lab Marco Pignatelli Míriam Ferrer Gonzalez Cancer Grand Challenges Cold Spring Harbor Laboratory science.org/doi/10.1126/sc…

This is a really important paper - immunogenic tumour associated antigens seem to be more associated with aberrantly expressed extragenic RNA than the classical mutations nature.com/articles/s4301…

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in Nature Genetics 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

Proud to share Jose M. Adrover’s (new PI The Francis Crick Institute) paper: As a postdoc (Cold Spring Harbor Laboratory/Johns Hopkins Medicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis. nature.com/articles/s4158… @JHU_BDP nature