2nd paper this year from our lab. Congratulations to Kemal Keseroglu and Oriana Zinani Ph.D. for publishing protocol paper on using single-molecule fluorescence in situ hybridization (#smFISH) and immunohistochemistry to count molecules in single cells in Zebrafish Rock!

Read about the ups, downs and eureka moments behind our recently published work nature. Thank you the Node for this blog.

nature the Node M. Fethullah Simsek Chandel Angad didar

Alev Lab and Pourquie ( Yuchuan Miao ) labs recently published 3-D human somitogenesis models nature + sharad_ramanathan lab CELL as well. Our two cents (spotlight Cell Stem Cell) on how they teach about conserved mechanisms to make somites: doi.org/10.1016/j.stem… #development

Tune-in for an amazing talk by M. Fethullah Simsek this Thursday.

To all the curious minds, talk starts at 12.30 pm EST, please do join it.

A spotlight on recent human stem cells models of somite segmentation from our lab. cell.com/cell-stem-cell…

Congratulations to Bibek on becoming Dr. Dulal! Well defended! 🎉

A review from our lab on the role of FGF Signaling in somitogenesis.

Congratulations Muhammed on starting your lab McMaster University . We are all so proud of you.

Congratulations to Chandel Angad on winning the poster award 👏🎉

Exciting news! Just published in Nature Communications: "Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes." #Zebrafish #Genetics #DevelopmentalBiology nature.com/articles/s4146…

Oscillatory control of embryonic development In this Review, Angad Singh Chandel, Kemal Keseroglu & Ozbudak Lab explore the diverse functional roles played by the oscillatory expression of bHLH family transcription factor Hes/Her genes and their targets: journals.biologists.com/dev/article/15…

Hey, Curious minds! Ever wondered how stem cells magically transform into the right cells at the right time? Or how nature creates beautiful patterns like somites? Explore the fascinating world of oscillatory Hes/Her genes in our review! #Science #STEM

We first summarize our favorite topic, somitogenesis. Describing how the oscillatory expression of Hes/Her genes and their targets is utilized by cells to measure time. Thereby creating periodic pattern of somites in space.

Then, we discuss the gatekeeping role of their oscillatory expression in neurogenesis, myogenesis and pancreas development. It ensures proper embryonic development by regulating proliferation-to-differentiation switch of stem cells and progenitor cells.

Congratulations Kemal Keseroglu and Ozbudak Lab. It was so much fun exploring the role of the genetic oscillators in embryonic development. Thanks Jason Tchieu for discussions and providing valuable feedback and thanks to Ben Caputo and Brady Cline for critical reading and editing.

The Rihel lab Anya Suppermpool Stephen Wilson Gareth Powell CityU Hong Kong Konstantinos Ampatzis Jeff Rasmussen Eric Peterman Lippincott-Schwartz Lab Dvir Gur Preprints (cont.): Florian Engert Misha Ahrens Alex Chen (Astroglial purinergic signaling/ Norepinephrine) biorxiv.org/content/10.110… SeuntjensLab Caroline Zandecki (Killifish/ Telencephalon/ Growth/ Neural diversity) biorxiv.org/content/10.110… Joachim Goedhart (EzReverse/ Color

🚨News alert !! Honored to be endowed with Robert Laughlin Rea Professor of Anatomy at Northwestern University!