Mindbogglingly incorrect. Leave the epidemiology to the epidemiologists please. But keep up the good work with the vaccines! Lots of exciting things in development.

Really enjoyed writing this journal club for Nature Reviews Molecular Cell Biology. Thanks for the invite and the chance to reflect on one of my favourite papers!

'Proteins do not evolve to cause disease --humans, mice, frogs, even sea anemones all produce Aβ.' A reminder that at picomolar (physiologic) concentrations, Aβ42 helps synaptic plasticity and memory. Sure, at the nanomolar scale it is as toxic as insulin.
nature.com/articles/s4158…

Honoured to be giving the Ipsen-Olsen lecture “Triangulation of evidence in aetiological epidemiology: principles, prospects, limitations” named after two great Danish epidemiologists dent.au.dk/en/display/art… on 23rd May at 13.00 (UK time). On-line link aarhusuniversity.zoom.us/j/66668105414

Viewpoint from Madhav Thambisetty and Robert Howard discusses how data gaps in published research impede clinicians’ ability to clearly discuss the risks and benefits of amyloid-lowering drugs for treating Alzheimer disease. ja.ma/44xljPo

This might be the editorial of the year.

What we do to older people in the name of safety can be awful. I hope JAMA Internal Medicine makes this open access.

Do read EW👇🏻👇🏻The argument transcends the folly of “thickened liquid” diets —> to the importance of evidence

Dementia is littered with interventions like thickened liquids & PEG tubes that became standard of practice on theoretical benefits without clinical evidence. My editorial in JAMA Internal Medicine gives 3 recs to consider if thinking about thickened liquids
jamanetwork.com/journals/jamai…

Excellent thread synthesizing our frantic work over the weekend resulting in a rapid response The BMJ . Some of the points we raise have not, to my knowledge, been discussed before and I suspect they are germane to other meta-analyses on this topic
bmj.com/content/385/bm…

Looking at Scales, Immunoreactivity, and Aβ42 levels explain why #lecanemab and #donanemab bring more risks than benefits to patients with #Alzheimers 🧵(1/7)

#FirstDoNoHarm

Karl Herrup Bruno P. Imbimbo Kasper Planeta Kepp Journal of Alzheimer's Disease

researchgate.net/publication/38…

Twitter has focused mostly on a very glaring error of using the standard error in place of the standard deviation, but there are many other methodological problems in this recent meta-analysis of psilocybin for depression.
bmj.com/content/385/bm…

Clearly ridiculous claims not backed up by peer reviewed RCTs. However, some of the hyperbolic claims made for the amyloid antibodies are just as wild and non-data based. Alzheimer’s people - please don’t be this guy.

with Alberto J Espay Karl Herrup Bruno P. Imbimbo Kasper Planeta Kepp in Journal of Alzheimer's Disease I co-wrote the following piece:

'Recalibrating the Risk-Benefit Profiles of Lecanemab and Donanemab: Scales, Immunoreactivity, and Changes in Amyloid-β42'

PDF here:
researchgate.net/publication/38…

EU life expectancy estimated at 81.5 years in 2023 🧓👶

Highest in:
🇪🇸Spain (84.0 years)
🇮🇹Italy (83.8)
🇲🇹Malta (83.6)

Lowest in:
🇧🇬Bulgaria (75.8 years)
🇱🇻Latvia (75.9)
🇷🇴Romania (76.6)

Learn more ➡️ europa.eu/!vppBxf

EU life expectancy increased by 0.2 years in 2023 when compared with 2019🧓

Largest increases in:
🇷🇴Romania (+1.0 year)
🇱🇹Lithuania (+0.8 years)

Largest decreases:
🇦🇹Austria & 🇫🇮Finland (both -0.4 years)
🇪🇪Estonia & the 🇳🇱Netherlands (both -0.2 years)

➡️europa.eu/!vppBxf

We argue that 'language should be prudently restrained' about mAbs in Alzheimer's to avoid overstatement and false hope.

We cite Sarah Ackley, PhD Maria Glymour Vincent Planche Nicolas Villain Alberto J Espay Kasper Planeta Kepp Kathy Liu Seb Walsh Robert Howard

researchgate.net/publication/38…

It pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:

GRADE continues to explore the optimal use of non-randomized studies in making optimal inferences for clinical decision making. pubmed.ncbi.nlm.nih.gov/36198367/

Spring. Finally!

Københavns Uni campus CSS. Best gem in town.

More evidence on the positive benefit of exercise on youth mental health.

⁦Kwadwo Kyeremanteng⁩, I thought you’d appreciate this ☺️ jamanetwork.com/journals/jamap…

I wonder if we teach regression to the mean enough in epi and biostats courses
A great introduction is here academic.oup.com/ije/article/34…