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Intriguing paper in this week's Science: a new, much cheaper approach for MRI scanning It's an MRI scanner that uses a 0.05 Tesla magnet (vs. the current 1.5 - 3 T) and operates at a fraction of the cost (~$22,000 for the hardware), time (<10 minutes), and noise of a current

🧠🐁 Interested in a quick / reliable / reproducible tool to quantify your fluoresently-tagged axons ? Check out AxoDen, a no-coding-needed web app and downloadable GUI ... Designed + developed entriely by the amazing Raquel Adaia Sandoval Ortega Raquel Adaia 🙌

A comprehensive overview yesterday of our efforts to develop disease models and therapeutic approaches for severe neurodevelopmental disorders. Thank you BBRFoundation for your support over the past decade! bbrfoundation.org/content/stem-c…

Cells located in the midline of the embryo play crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been

In the 1950s Brenda Milner changed the course of 🧠brain science by identifying the specific brain region crucial to memory formation and by identifying multiple memory systems. Today we celebrate her 106th! Happy Birthday Brenda Milner!🎂🎉 mcgill.ca/x/wYY

Took 1-8y off science for family during your postdoc or faculty position? Contact an NIH-funded lab to see if they will write a reentry with you. Please RT these little-known supplements: nigms.nih.gov/Research/Mecha…

Today we present precise detection of endogenous opioids using genetically encoded biosensors. Multiple early variants have been validated in labs, and we have now optimized, determined, and benchmarked the first-gen opioid sensors for both in vitro and in vivo applications.

My main postdoc work, 4.5 years in the making, is now out as a preprint: biorxiv.org/content/10.110…. We (myself, Isabel Low, Frances Cho, and Lisa Giocomo) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #tweeprint below! 1/13

Interested in using stem cells to create more mature human cortical neurons for studying intact living brain circuits? Excited to share our Nature Protocols Omer Revah, Felicity Gore, Konstantin Kaganovsky, Xiaoyu Chen, Karl Deisseroth, Sergiu P. Pasca nature.com/articles/s4159…

great scientist who cared and thought deeply about behavioral paradigms. Will be greatly missed

Interested in the intersection of brain organoids and bioelectronics? I highly recommend working with my colleague Xiao Yang when she opens her lab at Hopkins next year! Rigorous thinker who's passion for science shines through

Excited to share our updated preprint on the neural basis of foraging decisions! This work was co-led by Michael Bukwich (twitterless, now at UCL) and me, with major contributions from co-authors, and the incredible animation is by Kristian J Herrera. (1/12) biorxiv.org/content/10.110…

Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in

Today we report in Cell Stem Cell a systematic approach to generate neural #organoids resembling various domains of the neural axis. Neal Amin & Kevin Kelley developed a multiplexed morphogen screen to generate hundreds of #organoids that ultimately transcriptionally mapped to

Great to see our paper online! Amazing collaboration with Neal Amin over the years. With invaluable input from Konstantin Kaganovsky, Massimo Onesto, Jin, Yuki, James Patrick McQueen, MS, CSCS, Noah, and others in Sergiu P. Pasca group.

Tour de force systematically generating an incredible diversity of regionalized organoids. Grateful to contribute to this large effort driven by Kevin Kelley and Neal Amin in Sergiu P. Pasca lab.

I am no lord of any kind, but I assert here with all I have learned, this finding here is one (of the two or many) cloud that shadows the canonical neuroscience that 🧠memories are formed by synaptic plasticity. Keep this tweet and come back in 20 yrs. nature.com/articles/s4159…

Our 2024 CSHL conference on human brain development and stem cell models is in full swing, with over 300 participants! This year’s event features exciting new discoveries and dynamic discussions, driven largely by the energy & insights of trainees. A privilege to organize this

Turns out dendrites are important!

An important step in the maturation of this exciting, burgeoning field. See below for an international consensus on improving the reliability and reproducibility of organoid models, including assembloids and transplantation.