Sex difference in COVID19 severity and mortality. #COVID19 #SexDifference #Female newscientist.com/article/224089…

Leptin signaling in gut-brain axis supports nutrient absorption! #obesity #nutrients #leptin #weightloss #gutbrainaxis nature.com/articles/s4136…

Estrogen and gut satiety hormones in vagus-hindbrain axis #female #estrogen #foodintake #gutbrainaxis sciencedirect.com/science/articl…

Our latest @natmetabolism paper with @drdanbrierley @mkbholt @stefantrapp @neurolmr demonstrating that the central and peripheral GLP1 systems are separate. Targeting central GPL could enhance the effectiveness of GLP1R agonists #semaglutide. nature.com/articles/s4225…

Today in nature-- Monell Center researchers, led by AmberAlhadeff, share new findings that point towards a possible way to reduce adverse side effects of popular next-generation obesity medications like GLP1-based drugs, known as semaglutide and marketed as Ozempic® and Wegovy®

Drugs like Ozempic are great for weight loss, but they make some people feel sick. We discovered that the brain circuits mediating the appetite suppression are distinct from those that mediate nausea – a finding that may be leveraged to develop more selective GLP1-based drugs.

Refinement of our understanding of the distinct CNS pathways mediating reduction of food intake (in the hindbrain) vs aversive responses AmberAlhadeff Is selective targeting possible? nature.com/articles/s4158…

Guillaume de Lartigue nature Thanks so much Will 😀

Many people experience nausea from next-gen obesity drugs. Scientists have now pinpointed the brain circuits responsible for this, finding that feeling sick is not necessary for weight loss. I wrote about the work by AmberAlhadeff et al for nature: nature.com/articles/d4158…

So pleased to have been able to contribute to this beautiful work from the AmberAlhadeff group: nature.com/articles/s4158…. Not all GLP1R neurons in the DVC are the same! Understanding this heterogeneity is critical for future obesity drug design.

The neural circuits in the hindbrain that link satiety and aversion are shown to be separate, according to a paper in nature, raising the possibility of developing obesity drugs without the common side effects of nausea and vomiting. 🔒 go.nature.com/3S5p3Tb

Helen Raybould takes us thru her contributions to the understanding of Gut-Brain-Vagal interactions - leptin resistance, gut microbiota, CCK, GLP, and others at #SSIB2024 #DistinguishedCareerAward

The #SSIB2024 distinguished career award winner: Helen Raybould. She provided guidance to the next generation of trainees. Her advice, "If a door is ajar, Kick the door open."

Absolutely inspiring talk by Helen Raybould for her Distinguished Career Award. I am honored to have a trainee in common with her - Kuei-Pin Huang - who will be on the academic job market this fall!

As GLP-1 science expands beyond glucose control #T2D and #weightloss new indications are being explored in the clinic, highlighting potential roles for GLP-1 in neuroprotection, substance use disorders, metabolic liver disease and more Science Magazine science.org/doi/10.1126/sc…

“There’s always been a mystery about the relationship between being full and being nauseous,” said neuroscientist AmberAlhadeff How are we solving this mystery? Read more in this story from WHYY about the most recent scientific discovery out of Monell whyy.org/articles/weigh…

Go check out this exciting g work from #MCIP alum Kuei-Pin Huang on the role GLP1 signaling in satiety versus aversion. Congrats to the team!

❤️Our July issue is out❤️ Find out about the #brain-heart axis in health and disease, regulation of arterial adaptation to blood flow, targeting cardiac fibroblasts to prevent #fibrosis, and more! nature.com/natcardiovascr…

So happy to share our new work that is now out @sciencemagazine: We show how neurons in the mouse zona incerta (ZI) modulate infant social behaviors and learning. This work was led by the AMAZING graduate student Yuexuan Li Yuexuan Li 李玥璇. 🎉science.org/doi/epdf/10.11… #ScienceResearch

The transformative peptide biology that is reshaping the #obesity therapeutic landscape Cell An exciting decade unfolds in the metabolic medicine clinic #weightloss