Online now!📲

Inhibition of #autophagy -related protein 7 enhances anti-tumor #immuneresponse and improves efficacy of #immunecheckpointblockade in microsatellite instability #colorectalcancer

Full text👇
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#Cholesterol
#Microsatelliteinstability

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METTL3 recruiting M2-type immunosuppressed macrophages by targeting #m6A -SNAIL-CXCL2 axis to promote #colorectalcancer pulmonary metastasis

For free💻
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#Macrophages
#Epithelialmesenchymaltransition
#RNAmodification

Using different in vitro NSCLC models, researchers showed that NSCLC cells with low #HERC5 expression had increased malignant and invasive properties.

The Journal of Experimental & Clinical Cancer Research study comes from the University Medical Center Hamburg-Eppendorf's Wikman Lab: bit.ly/43YWyet

New study!

HERC5 downregulation in #nonsmallcelllungcancer is associated with altered energy #metabolism and #metastasis

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#Mitochondria
#Warburgeffect

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Blood-based biomarkers in patients with #nonsmallcelllungcancer treated with #immunecheckpointblockade

Full text⤵️
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#Liquidbiopsy
#Immunotherapy

New!🔥

The localization, origin, and impact of #platelets in the #tumormicroenvironment are tumor type-dependent

For free⤵️
jeccr.biomedcentral.com/articles/10.11…

#Vascularintegrity
#Thrombocytopenia

Just published!🍾

A paclitaxel-hyaluronan conjugate (ONCOFID-P-B™) in patients with BCG-unresponsive carcinoma in situ of the bladder: a dynamic assessment of the #tumormicroenvironment

Open access🔓
jeccr.biomedcentral.com/articles/10.11…

#Bladdercancer
#Macrophages
#Hyaluronicacid

New!🌸

𝐇𝐒𝐏𝐀𝟒 𝐮𝐩𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐢𝐧𝐝𝐮𝐜𝐞𝐬 #𝐢𝐦𝐦𝐮𝐧𝐞𝐞𝐯𝐚𝐬𝐢𝐨𝐧 𝐯𝐢𝐚 𝐀𝐋𝐊𝐁𝐇𝟓/𝐂𝐃𝟓𝟖 𝐚𝐱𝐢𝐬 𝐢𝐧 #𝐠𝐚𝐬𝐭𝐫𝐢𝐜𝐜𝐚𝐧𝐜𝐞𝐫

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#Immunotherapy

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GPR65 sensing tumor-derived lactate induces HMGB1 release from #TAM via the cAMP/PKA/CREB pathway to promote #glioma progression

Read here👇
jeccr.biomedcentral.com/articles/10.11…

#Lactate
#Tumorassociatedmacrophage

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Essential role of PLD2 in #hypoxia -induced #stemness and therapy resistance in #ovariantumors

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#PhospholipaseD

New!⛳️

TRF2 as novel marker of tumor response to #taxane -based therapy: from mechanistic insight to clinical implication

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#BreastCancer
#TelomericBindingFactor
#Autophagy
#DrugSensitivity

New Review!🎯

𝐀 #𝐠𝐥𝐮𝐭𝐚𝐦𝐢𝐧𝐞 tug-of-war 𝐛𝐞𝐭𝐰𝐞𝐞𝐧 𝐜𝐚𝐧𝐜𝐞𝐫 and 𝐢𝐦𝐦𝐮𝐧𝐞 𝐜𝐞𝐥𝐥𝐬: 𝐫𝐞𝐜𝐞𝐧𝐭 𝐚𝐝𝐯𝐚𝐧𝐜𝐞𝐬 𝐢𝐧 𝐮𝐧𝐫𝐚𝐯𝐞𝐥𝐢𝐧𝐠 𝐭𝐡𝐞 𝐨𝐧𝐠𝐨𝐢𝐧𝐠 𝐛𝐚𝐭𝐭𝐥𝐞

Enjoy!🍸
jeccr.biomedcentral.com/articles/10.11…

#Metabolism
#ImmuneCells
#TumorMicroenvironment

Featured Review👇
𝐑𝐞𝐠𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦𝐬 𝐨𝐟 𝐢𝐦𝐦𝐮𝐧𝐞 𝐜𝐡𝐞𝐜𝐤𝐩𝐨𝐢𝐧𝐭𝐬 𝐏𝐃-𝐋𝟏 𝐚𝐧𝐝 #𝐂𝐓𝐋𝐀 -𝟒 𝐢𝐧 𝐜𝐚𝐧𝐜𝐞𝐫

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jeccr.biomedcentral.com/articles/10.11…

#CancerImmunotherapy
#PDL1
#DrugIntervention

New!📌

Validation of a multiomic model of #plasmaextracellularvesicle PD-L1 and radiomics for prediction of response to #immunotherapy in NSCLC

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jeccr.biomedcentral.com/articles/10.11…

#LungCancer
#Immunecheckpointinhibitor
#LiquidBiopsy
Christian Rolfo

Online!📲

#𝐌𝐞𝐬𝐨𝐭𝐡𝐞𝐥𝐢𝐧 𝐩𝐫𝐨𝐦𝐨𝐭𝐞𝐬 #𝐛𝐫𝐚𝐢𝐧𝐦𝐞𝐭𝐚𝐬𝐭𝐚𝐬𝐢𝐬 𝐨𝐟 #𝐧𝐨𝐧𝐬𝐦𝐚𝐥𝐥𝐜𝐞𝐥𝐥𝐥𝐮𝐧𝐠𝐜𝐚𝐧𝐜𝐞𝐫 𝐛𝐲 𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐧𝐠 𝐌𝐄𝐓

Full text⤵️
jeccr.biomedcentral.com/articles/10.11…

#Bloodbrainbarrier

New!🍀

A phase I open-label, dose-escalation study of NUC-3373, a targeted thymidylate synthase inhibitor, in patients with advanced cancer (NuTide:301)

Open access🔓
jeccr.biomedcentral.com/articles/10.11…

#Fluorouracil
#clinicaltrials
#Cancertherapy
#SolidTumor

Enjoy JECCR publication!🍷

#Transcriptionalregulation of #cancerstemcell : regulatory factors elucidation and cancer treatment strategies

See here👇
jeccr.biomedcentral.com/articles/10.11…

#Signalingpathway
#Epigenetics

Just Published!🌸

Tumor suppressor role of the complement inhibitor CSMD1 and its role in TNF-induced #neuroinflammation in #gliomas

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jeccr.biomedcentral.com/articles/10.11…

#Tumornecrosisfactor
#Inflammation
#BrainTumor

New study!🏹

A high-content screen of FDA approved drugs to enhance #CART cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface via PKCα activation

For free⤵️
jeccr.biomedcentral.com/articles/10.11…

#Tcell
#Osteosarcoma