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📺TIMESPAN's second #masterclass is now live! What are directed acyclic graphs? What can family data tell us about unmeasured confounding? And how does #ADHD tie in❓ ❗Learn it all in the masterclass by Ralf Kuja-Halkola, from Karolinska Institutet & Biostatistics Group at MEB, Karolinska Institutet ▶ youtu.be/mwoVMLR_Eyw

With UK Biobank metabolomics from Nightingale Health now available for 300K+ participants, one of the more intriguing biomarkers is GlycA. But what is GlycA and what is its underlying biology? Dr. Scott C. Ritchie & co investigated this a few years back cell.com/cell-systems/p…

🎉 1/8 We are thrilled to unveil our inaugural publication, now available in Cell. This achievement marks a significant milestone resulting from our collaborative endeavors with prominent leaders in aging, contributing to the Biomarkers of Aging Consortium.

Thrilled to receive the best poster award at #EuGMS2023! 🥳

📝 The 1st paper of the EPI-FRAIL network! "Recent developments in #frailty identification, management, risk factors and prevention". Great collaboration with Elsa Dent, Peter Hanlon, Davide L Vetrano, Marc Sim, Sandra Shi et al. #OpenAccess #geriatrics doi.org/10.1016/j.arr.…

Is there a causal connection between #epigeneticclock & #frailty? Our new paper shows a unidirectional relationship that higher #DunedinPACE predicts higher FI, supporting the #geroscience hypothesis Sara Hägg Ida Karlsson Gerontological Society of America (GSA) Oxford Journals doi.org/10.1093/gerona…

🎓Successfully defended my PhD thesis on Nov 16, 2023🙌Huge thanks to my supervisors Juulia Jylhävä Sara Hägg Ralf Kuja-Halkola Chandra Reynolds for their guidance & support in the past 4 yrs. Couldn’t have done it without you🙏 Link to my thesis: hdl.handle.net/10616/48773

I am thrilled to present our new study out in nature where we measure aging at organ-level resolution in living people with large-scale plasma proteomics + ML! From Tony Wyss-Coray lab, co-led with former grad student Jarod Rutledge, Ph.D. 1/12

Clinical biomarker-based biological age, which uses measures like telomere length, epigenetic clocks and composite biomarker predictors, is a robust predictor of stroke and dementia risk New research by Jonathan Mak et al, read it here: jnnp.bmj.com/content/early/…

Online now! Identification of causality-enriched CpGs linked to #aging using Mendelian Randomization and development of epigenetic clocks, DamAge and AdaptAge, more accurate at tracking age-related changes @kejunying Gladyshev Lab rdcu.be/dwrVd nature.com/articles/s4358…

Happy to share our latest paper in Aging_Cell🎉 Our EWAS in 2 twin cohorts identified new CpGs associated with #frailty. Big thanks to all my PhD supervisors & collaborators! Link: doi.org/10.1111/acel.1… Sara Hägg Laura Kananen Ida Karlsson Ralf Kuja-Halkola

What's more convincing? p = 0.04 in a sample of 10 or p = 0.04 in a sample of 1,000,000? 🧵

The signal is in the instability. Deficits accumulate when damage goes unremoved/unrepaired. In a sufficiently safe environment there is time for recovery to work when repair times are not prolonged. Unsafe environments challenge by a higher damage rate and longer repair times.

Impressive study showing that inhibiting interleukin-11, a pro-inflammatory cytokine, extends lifespan in mice by 25%. Both genetic deletion and an anti-IL-11 drug worked, and it's exciting that anti-IL-11 therapies are already in human clinical trials. nature.com/articles/s4158…

Assessing older patients for frailty enables clinicians to tailor clinical care, including decisions about stressful treatments. The authors review the assessment, pathophysiology, and management of frailty. Read the full review: nej.md/3WV9SyV

Our aging paper just came out. Two periods of major changes: Mid 40s and 60s. Check it out doi.org/10.1038/s43587…

We are delighted to share our findings on biological aging of different blood cell types! 🥳🌼 once again, so happy to have such a great co-authors ⁦Saara Marttila⁩ ⁦Jonathan Mak⁩ ⁦Sara Hägg⁩ and others enabling the work! 👇 link.springer.com/article/10.100…

Warm welcome to our new #BMCGeriatr Editorial Board Members Jonathan Mak, Kallol Kumar Bhattacharyya and Sayeh Bayat. We are looking forward to working with you. Interested in joining #BMCGeriatr? Visit <bmcgeriatr.biomedcentral.com/join-our-edito…>