Congratulations Alex MacKerell !! Well deserved!!

Happy that TRIANA Biomedicines has now officially launched! We collaborate with their team to rationally design molecular glues. TRIANA has a technology platform that's truly transformative, and a very strong team - I'm excited to see where these efforts will lead!!

I know the Triana team well and they're terrific, this would be a great opportunity for someone interested in structure-based modeling of molecular glues / targeted protein degradation! trianabio.com/job-posting-sr…

Trying out Mastodon! I'll be at @[email protected]

Congrats to Swayam Prabha, MBA, PhD, a member of the Cancer Signaling and Microenvironment research program at Fox Chase, who was recently awarded a $792,000 American Cancer Society research scholar grant to investigate new methods for treating lung cancer! bit.ly/3BiFaEF

Interested in protein design, deep learning, computational biophysics? Or computational RNA folding, vaccines, enzymes, antibodies, biomaterials, machine learning? Become a Rosetta Commons undergraduate summer intern (U.S. National Science Foundation #REU) or a postbaccalaureate fellow (#RaMP)! [thread!]

"As a patient and as an advocate, I passionately urge you to support LFSA by making a gift and becoming an advocate yourself... LFSA is connecting resources and communities around the world to improve the future for all of us." - Elizabeth Cowles Johnson lfsassociation.org/holidays22/

New postdoc position in our group! Come and work at the intersection of machine learning, molecular dynamics, biophysics and drug design! 💻🧠🧪💊careers.msu.edu/cw/en-us/job/5… RTs appreciated!

Targeted #MDM2 Degradation Reveals a New Vulnerability for #p53 Inactivated #TripleNegativeBreastCancer, by Clare Adams, Joseph Salvino, Christine Eischen et al. bit.ly/3K45tnh Sidney Kimmel Comprehensive Cancer Center Thomas Jefferson University #TNBC #PROTAC

I am hiring a computational scientist to join the The Precision Immunology & Microbiome Medicine Laboratory at UPenn! If you have an interest in #multiOMIC analysis & integration of #microbiome, metabolome & immune profiling data, apply here wd1.myworkdaysite.com/en-US/recruiti… Please RT 🙏🏿

Certain MEK inhibitors induce a complex between #MEK & difficult-to-degrade #cRAF. This allows bystander degradation of recalcitrant cRAF w/ #PROTACs targeting MEK. Excellent study by the Duncan & Jin labs Fox Chase Cancer Center Icahn School of Medicine at Mount Sinai bioRxiv biorxiv.org/content/10.110…

Excited to finally share some work that resulted from a collaboration between Pitt, CAMH, and UPenn. The work involved the creation of an open-source tool for fingerprint similarity searches and resulted in the discovery of new 4R-tau radioligands. pubs.acs.org/doi/10.1021/ac…

The very first preprint from our lab!! We repurposed a rapidly internalizing receptor TfR1 for membrane protein degradation. We show it works on single-pass, multi-pass, native and synthetic receptors. The overexpression of TfR1 on cancer cells offers potential tumor selectivity.

We are recruiting postdocs! Interested in high-throughput biophysics? I'd love to talk to you! See rocklinlab.org/news/hiring-po…

Fox Chase is pleased to announce the hiring of Khadijah A. Mitchell (DrDij), PhD, MS, as an Asst. Prof. in the Cancer Prevention and Control Research Program. Read more on Mitchell's research focus in cancer disparities, and leadership in health equity: bit.ly/452b2dj

Excited to make this important work public! It turns out that building *truly useful* AI models for inhibitor/kinase interactions remains really challenging, as demonstrated by the careful studies of Gabriel Ong and Kirubakaran Palani. biorxiv.org/content/10.110…

Pleased to announce the latest additions to the TRIANA team. Welcome Vito Palombella, Reza Mazhari and Brian Jones! trianabio.com/press-release-…

Please join us! 🏳️‍🌈🏳️‍⚧️ 🏳️‍🌈🏳️‍⚧️ 🏳️‍🌈🏳️‍⚧️

Join us at AbbVie - two new positions available! First one seeks a creative scientist for AI/ML applications in our global Comp Drug Discov team (N Chicago / Mass / SF / Germany). Full details in the link! jobs.smartrecruiters.com/AbbVie/3743990…

Join us at AbbVie - two new positions available! Second one seeks a trailblazing leader to bolster application of AI/ML methods for drug discovery programs, and guide the future direction of AI/ML in this space. (N Chicago / Mass / SF / Germany). jobs.smartrecruiters.com/AbbVie/3743990…