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Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections dlvr.it/T3M39r

Development of Activity-Based Probes Targeting FphE for Specific Detection of Staph aureus Infections | Journal of the American Chemical Society Matthew Bogyo Jeyun Jo Tulsi Upadhyay Stanford University Stanford Medicine NYT Science #Detection #StaphAureus #Infections pubs.acs.org/doi/10.1021/ja…

Structures just released rcsb.org/structure/8T87 rcsb.org/structure/8T88 determined in collaboration with Stanford University Matthew Bogyo and my lab at Otago Biochemistry - JACS paper on Probes for Specific Detection of Staph Infections doi.org/10.1021/jacs.3… Jeyun Jo Tulsi Upadhyay +others

Our review (Maly Cosco) on ratiometric optical imaging methods for detecting enzyme activity is out. Check it out to learn more about recently developed probes that use multiple dyes to overcome some of the limitations of quenched fluorescence agents. authors.elsevier.com/a/1ijE34sz6MMd…

17 years in the making.. We are super excited to finally achieve alcohol-alcohol cross-coupling enabled by the powerful SH2 radical sorting! Great work Jerry, Nick, Jay, James, Colin and Robert. Big shout out to our collaborator Jesus from Janssen Spain. science.org/doi/full/10.11…

Drug redesign to boost stem cell regeneration cen.acs.org/pharmaceutical… via C&EN (Chemical & Engineering News)

Nice review on covalent warheads: pubs.acs.org/doi/10.1021/ac…

Check out the latest in our efforts to design better optical contrast agents for image guided surgery. We used iBodies as a scaffold. Great collaboration with Jan Konvalinka Lab. Nice work from Martin Hadzima Josh Yim Franco Faucher. biorxiv.org/content/10.110…

The published version of our bioRxiv paper is now out and open access! Check it out to learn about our efforts using fluorescent polymer-based iBody probes for image guided surgery applications. pubs.acs.org/doi/10.1021/ac…

Our paper using mixed alkyl aryl phosphonates to identify serine hydrolases in Plasmodium falciparum that are potential drug targets is out. Great work from John Bennett and collaborations with The Fidock Lab. Free Download here -authors.elsevier.com/a/1jarB8jWWJxM… cell.com/cell-chemical-…

An inspiring read! Synthesis at the Interface of Chemistry and Biology | Accounts of Chemical Research pubs.acs.org/doi/10.1021/ac…

Cool new preprint on prodrugged molecular glues by ⁦Sarafan ChEM-H⁩ institute scholar Nathanael Gray and coworkers ⁦Stanford Cancer Institute⁩ ⁦Stanford Medicine⁩ Charged Molecular Glue Discovery Enabled by Targeted Degron Display | bioRxiv biorxiv.org/content/10.110…

Excited to present the first paper from the Park group, published today in Science Magazine! We found a user-friendly, mild reaction conditions for exchanging an oxygen in heterocycles with nitrogen groups. Congrats Donghyeon, Jaehyun, and the team! science.org/doi/10.1126/sc…

Radical Polarity | Journal of the American Chemical Society nagib lab Ohio State Total Synthesis and Methodology Highlights #Radical #Polarity pubs.acs.org/doi/10.1021/ja…

The big day is here! The Bay Area Chem Bio symposium, kicked off by ⁦Matthew Bogyo⁩ ⁦Francis Group 🧪⁩ and ⁦Jim Wells Lab⁩ !

After a lot of work by Sijie Wang to finish the project I started while at Genentech on sabbatical last year, we have finally posted the results to bioRxiv. biorxiv.org/content/10.110…

A great collaboration between Bogyo lab and Genentech. I had a lot of fun learning mRNA display and warhead encoding! Big thanks to all collaborators involved in this project! Emily C. Woods Jeyun Jo JiyunZhu Nikki Pedowitz Tulsi Upadhyay John Bennett

Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. Check it out!biorxiv.org/content/10.110…

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein–Protein Interactions Using Phage Display | Journal of the American Chemical Society Stanford University Stanford Medicine Matthew Bogyo pubs.acs.org/doi/10.1021/ja…

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work by @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. link.springer.com/article/10.103…