Bioconductor 3.16 is Released. Thanks to all developers and community members for contributing to the project! Please see the full release announcement: bioconductor.org/news/bioc_3_16… #Rstats Bioconductor

.Jean-Philippe Fortin Genentech crisprVerse enables efficient gRNA design and annotation for methods including CRISPRko, CRISPRa, CRISPRi, CRISPRbe and CRISPRkd, enabled for RNA- and DNA-targeting nucleases, including Cas9, Cas12 and Cas13 go.nature.com/3DBIsmD

Today we report in Nature Biotechnology the conversion of adenine base editors (ABE) into next-generation cytosine base editors (TadCBEs) with high on-target activity and reduced off-target activity using phage-assisted continuous evolution (PACE). 1/14 drive.google.com/file/d/1XY3QG-…

Thrilled to share our lab’s first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal. cell.com/cell-genomics/…

#Illumina's MethylationEPIC v2.0 BeadChip is now available! 935K methylation sites for the same price as EPICv1.0. Learn more here: sapac.illumina.com/content/dam/il…

I am hiring a 2023 summer intern at Genentech on microscopy-based image processing and statistical analysis. If you happen to be or know anyone who is interested and has relevant experience, please reach out or spread the word! roche.wd3.myworkdayjobs.com/ROG-A2O-GENE/j…

New preprint! What is all that non-coding DNA doing? To understand if and how non-coding sequences regulate gene expression, we need scalable and reliable perturbation methods Delighted to present the ENCODE Project Multi-center integrated analysis of non-coding CRISPR screens!

Excited to announce the release of #ggplate on CRAN! ggplate is an R package that enables easy visualization of culture and microplate data. Find out how to use it here: jpquast.github.io/ggplate/ 1/5 #rstats #DataScience #datavisualization #Biology #microbiology #AcademicChatter

Precise transcript targeting by CRISPR-Csm complexes go.nature.com/3XTaIJQ

a year ago we (+Aaron Lun) announced Kana (kanaverse.org/kana/), to perform #singlecell analysis in the browser powered by #webassembly. This week we released version 3 to support multi-modal data analysis, gene set enrichment and exploration of pre-analyzed results (1/n)

Do you ever look at something amazing someone in your lab has done and say "Wow; this is awesome!"? Well, here's a very short story starring Dongze He! As part of simpleaf (github.com/COMBINE-lab/si…), we rely on another package we wrote called pyroe (github.com/COMBINE-lab/py…). 1/15

Our Data Science and Statistical Computing group in the Genentech Computational Hub is seeking a highly motivated Principal Scientist to lead the development of methods and computational tools for genomics workflows. #hiring #genentech #bioinformatics careers.gene.com/us/en/job/GENE…

At the core, the pipeline is using the excellent packages from the #crisprVerse suite for #R #bioconductor, developed by the team around Jean-Philippe Fortin . Many thanks for this great foundational work 👏

Now online! New-preprint from the always-brilliant Kristel Dorighi with essential contributions from many others at Genentech; enhanced Cas9 base editing (BE) for drug resistance variant discovery. biorxiv.org/content/10.110…

Thrilled to share our pre-print describing a new enAsCas12a transgenic mouse model + genetic screening platform. Made in close collaboration with teams led by @marcoherold_j Professor Marco Herold (WEHI (Walter and Eliza Hall Institute)/@onjcri) & @jaypykw (@Genentech)! 1/9 biorxiv.org/content/10.110…

Published (and open access)! Super excited to share the final version of our manuscript describing an enhanced mutagenic base editing platform for use in functional genomic screening. See original tweetorial for more details. cell.com/cell-reports/f…

Powerful use of the RNA-targeting Csm complex! We've now extended the crisprVerse to make CRISPR-Csm gRNA design easy: github.com/crisprVerse/Tu…

Wish you could develop Bioconductor-like workflows in Python? You can! Don't miss out on Jayaram Kancherla's BiocPy workshop tomorrow at #bioc2024 cfp.bioconductor.org/2024/talk/SECD… BiocPy: github.com/BiocPy