Monday, May 20th, we'll be hosting a symposium featuring 10 talented Graduate Student Rising Stars, starting at 9am in HSEB 1700! U of U NUIP Annalise Bond Heankel Lyons Gina Wade NyJaee Washington Marissa Kyle Flickinger Ngozi D. Akingbesote Samantha Zepeda Duc Huynh (he/him/his) Daniel Colón Ramos

So excited to have been given the opportunity to share my work at the Rising Stars Symposium at University of Utah!

V happy to share my work in DeBerardinis Lab Children’s Research Institute at UT Southwestern from past 2 yr! In equal collab with Tony Rodrigues, Dwendscheck (dwendscheck.bsky.social), Jorge Azevedo’s lab, Warscheid lab, we have discovered PEX39, the first human peroxisomal biogenesis protein (peroxin/PEX) found in > 20 yr! biorxiv.org/content/10.110…🧵

a big congrats to Gavin for receiving an undergrad summer research award from UW–Madison Biochem in the afternoon and then a campus-wide sophomore research fellowship at the Chancellor’s award ceremony, very well deserved! super proud, keep up the awesome work!!

New preprint! Led by Clara Frazier, we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of protein C termini that mimics the logic of peptide bond formation in biology. UW–Madison Biochem UW-Madison IPiB biorxiv.org/content/10.110…

enjoy the awesome experience, science, and people Kyle Flickinger and Gina Wade! super proud of & very excited for you both! way to rep metabolism & interdisciplinary work UW-Madison IPiB UW–Madison Biochem Morgridge Institute cc: Judith Simcox PhD Rutter Lab Gregory Ducker

huge congrats to our newest PhD candidate! Carlos Mellado-Fritz crushed his prelim this afternoon!! 🎉 a very proud adviser, cheers!

Happy to share our new paper in print today in Science Advances exploring nutrient utilization by CD8 T effector cells in vivo using infusion of 13C tracers. Great work by Eric Ma, Mike Dahabieh and collaborators at Van Andel Institute (VAI) and Agios. science.org/doi/10.1126/sc…

FOR THE LOVE OF PURINES: We are truly excited to share our latest work on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors Cell Press. A huge team and collaborative effort! Congratulations, ALL!

If you're interested in anti-tumor immunity and metabolism... Arg:Orn ⚖️ TAM/CD8 Article: nature.com/articles/s4301… News and Views: nature.com/articles/s4301…

A while back I made a joke that DMEM was like feeding your cells Gatorade... so I did that experiment to see how accurate that statement was... Turns out gatorade has some neat effects including this elevation of GDP-fucose... #messingaroundinlab

New preprint w/ Ana Paula Arruda! Tour de force from grad student extraordinaire Alyssa Mathiowetz! >20 CRISPR screens enabled the discovery of a key role for CLCC1 in hepatic neutral lipid flux and nuclear pore complex assembly. Many surprises! #LipidDroplets 1/3 biorxiv.org/content/10.110…

1/Sharing a new セルメタ paper from Zheng Wu, showing that cancer cells need purine salvage to grow during ETC inhibition. This allows them to tolerate suppression of de novo purine synthesis, which requires the ETC. -RJD sciencedirect.com/science/articl…

Excited to share a new paper from the super creative and talented Eden! Eden engineered droplet-forming sequences to act as regulatable glues for stitching microtubules together inside living cells 🧫🧪

The Weeks Lab UW–Madison Biochem is hiring at all levels! Broadly, our lab uses engineered enzymes to decipher cellular signaling to advance biological discovery and therapeutic development. If this sounds exciting to you, please reach out! Reposts appreciated. 🧪weekslaboratory.org

Today in @nature, we discover a new enzyme in mammalian taurine metabolism- and uncover a chemical connection between diet, genetics, and body weight. Congrats Wei Wei (魏伟) Sarafan ChEM-H Stanford Pathology Michael Fischbach Cholsoon Jang SvenssonLab Lingyin Li Lab nature.com/articles/s4158…

1/Out today @nature, a paper from Divya Bezwada and DeBerardinis Lab Children’s Research Institute at UT Southwestern about metabolism in human clear cell renal cell carcinoma (ccRCC). Divya identified an unexpected metabolic change that allows these tumors to metastasize. 🧵below.-RJD nature.com/articles/s4158…

thanks, Zeribe Nwosu! super excited to make my first return trip far above cayuga's waters in 20 years! many fond memories, including from the decent portion of my waking hours spent in olin hall 😀 go big red!

We are excited to host the Midwest Metabolism Meeting (M3) this week! Lurie Cancer Center Northwestern Feinberg School of Medicine. Join us to attend exciting talks and poster presentations by postdocs and students and a keynote address by Prof. Richard DiMarchi Indiana University Chemistry Department cancer.northwestern.edu/events/profess…

a beautiful seminar at M3 from Kim Huggler! also tons of great discussion at Kyle Flickinger poster! big thanks to Ben-Sahra Lab, Clara Peek, and Nav for organizing; Northwestern Medicine Lurie Cancer Center for hosting! fantastic meeting with an amazing community to catch up with!