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Join our lab at Stanford University! Several staff positions available in my group, including for a lab manager. Please share 👇 careersearch.stanford.edu/jobs/administr… careersearch.stanford.edu/jobs/2-years-f… More on the lab work here: pascalab.org

Very impressive model recapitulating human ascending pathway! Beautiful and astonishing work from my colleagues Ji-il and Kent in the Sergiu P. Pasca lab!

Excited to see this well designed study and the innovative finding of the roles of dynorphin signaling in threats and defensive behaviors! Another great application of our opioid detecting biosensors. Huge congrats to my mentor-like collaborator Hugo Tejeda, Huikun and team!

Stunning and decade-long study with therapeutics for Timothy Syndrome from the Sergiu P. Pasca lab! Great work Xiaoyu Chen Fikri Birey!

Ecstatic to bring you our new preprint and the bulk of my thesis work investigating sex differences and examining the effects of mosaicism in Rett syndrome mouse and human cortex at the single cell level. biorxiv.org/content/10.110…

Excited to share our work in the mbruchas lab on how endogenous opioids promote goal-directed behavior, funded by NIDAnews. I am currently on the job market and this work will form the basis of my research program. biorxiv.org/content/10.110…

Cells located in the midline of the embryo play crucial roles in development. These cells often influence cell fate decisions and guide axons to establish bilateral connections. Despite their importance, studying these transient cells and their complex interactions has been

Excited to share my first paper from Inagaki Lab Max Planck Florida Institute for Neuroscience! How does the “timer” in our brain control movement? We discovered specialized computational roles of the frontal cortex and striatum that implement such an action timer⏱️ biorxiv.org/content/10.110…

Interested in using stem cells to create more mature human cortical neurons for studying intact living brain circuits? Excited to share our Nature Protocols Omer Revah, Felicity Gore, Konstantin Kaganovsky, Xiaoyu Chen, Karl Deisseroth, Sergiu P. Pasca nature.com/articles/s4159…

Step into the world of *Avatar*! Congrats to my colleague Xiao Yang on this exciting new journey. A brilliant and meticulous scientist, offering a fantastic opportunity for anyone passionate about BMI and biomaterials for neural research.

Congrats to my friend Osman Sharifi on completing his thesis! The team used longitudinal single-nucleus RNA sequencing with Rett syndrome mouse model, uncovered stronger transcriptional dysregulation in females, and identified key disease-related changes nature.com/articles/s4200…

Today we introduce human neural loop #assembloids created from 4 parts derived from stem cells to study the cortico-striato-midbrain-thalamo-cortical pathway and to model neurodevelopmental disease Work led by the remarkable Ji-Il Kim and Yuki Miura in the lab. Also in

Glad to announce a new edition of our popular, free, hands-on Stanford University course on making, probing and manipulating neural #assembloids and #organoids Organized by an amazing trio in the lab: Rebecca J. Levy 𝗔𝗹𝗳𝗿𝗲𝗱𝗼 𝗠 𝗩𝗮𝗹𝗲𝗻𝗰𝗶𝗮, 𝗣𝗵𝗗 🔬 and Merve Avar Deadline in mid-December Supported

In this week’s nature, we publish a group effort to outline a framework for studies with neural #organoids, #assembloids and transplantation. More details below 1/n

As stem cell-based modeling of the human nervous system and disease advances, we recently shared a group-effort framework in nature on designing experiments with #organoids, #assembloids, and transplantation Here a few key takeaways in 6 slides👇

Today in nature, we report human sensory #assembloids—the most complex 3D assembloids to date—comprising four integrated parts to recapitulate aspects of the spinothalamic pathway that processes pain stimuli. We use this model to investigate cellular/early circuit level