1) Excited to share a ms entitled: Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D #organoid sheets. It describes an alternative to #Matrigel biorxiv.org/cgi/content/sh… A thread:

Out now in Science Advances: Antibiotics damage the colonic mucus barrier in a microbiota-independent manner Shai Bel Meital Nuriel-Ohayon science.org/doi/10.1126/sc…

Tomo Mizutani & Matteo Boretto selected 4 spontaneous colon #cancer mutations by sequential withdrawal of growth factors from mismatch repair-deficient #organoids. Mutations resemble those of Lynch syndrome & MSI-H patients tumors. nature.com/articles/s4301…

Check out this new paper from the Sander van Kasteren and daniel rozen labs LED3 hub (inactive account). Labeling of newly synthesized proteins with BONCAT identifies up- and downregulated proteins in S. aureus persisters. Very happy that we could make a small contribution biorxiv.org/content/10.110…

REVIEW Science Magazine Chemical genetic approaches to dissect microbiota mechanisms in health and disease science.org/doi/10.1126/sc…

Check out this preview of the Cell Host & Microbe paper from the StrowigLab in collaboration with #HIRI's Jörg Vogel. ⬇️

Interesting paper by the group of Michael Bollong of Scripps Research in J. Am. Chem. Soc.. A high-throughput assay for cysteine-reactive electrophiles based on luciferase activity allows identification of azetidinyl oxadiazoles as cysteine-reactive electrophiles. pubs.acs.org/doi/10.1021/ja…

Interesting ChemRxiv preprint by the group of Thomas Poulsen with first author Esben Svenningsen. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and specifically investigated difference in normoxia and hypoxia. doi.org/10.26434/chemr…

Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with Alexey Nesvizhskii in Fragpipe in this exciting system. chemrxiv.org/engage/chemrxi…

Interesting paper by the group of Rui Wang in Analytical Chemistry. They systematically studied several activated esters with heteroaromatics in the leaving group and show strong, tunable lysine labeling with high hydrolytic stability. #ChemBio pubs.acs.org/doi/10.1021/ac…

A 3-year postdoctoral position in antiphage immunity hosted by my lab (Lund), co-supervised Gemma C Atkinson (co-PI, structural bioinformatics, Lund University) and Pontus Gourdon (co-PI, cryo-EM, Lund University and University of Copenhagen). PleaseRT! lu.varbi.com/en/what:job/jo…

Featured Article: C. jejuni promotes CRC metastasis CRC tumors enriched with Campylobacter, whose production of genotoxin accelerates tumor metastasis, offering insight into the role bacteria play in metastasis cell.com/cell-host-micr…

📢 New in Nature Communications! Researchers at the University of Hong Kong developed human #RespiratoryOrganoids that reproducibly propagated human rhinovirus C to characterize the virus-host interaction. 🦠 Learn more: go.nature.com/4gGIrjz

nature.com/articles/s4158…

Breakthroughs in medicine start with research — and lead to better lives. Ask Dr. Kevan Herold of Yale School of Medicine. His team’s work led to approval of the first drug able to delay the onset of Type 1 diabetes. He’s seen firsthand the profound effects on young patients

Scientists from Peking University (Peking University) developed a microinjection-based method to quantify the growth time-dependent nonlinear elasticity of intestinal #organoids. 🧫 💡Learn more about their research: bit.ly/3Fk0jTu

Featured Article: Microbiota changes with CRC tumor location Fecal microbial changes in proximal vs distal CRC w/specific microbes linked to tumor location. Multi-cohort analysis demonstrates diagnostic potential of location-specific fecal bacteria in CRC cell.com/cell-host-micr…

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work by @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. link.springer.com/article/10.103…

Congrats to postdoc Zhe Zhou on her paper out today in Cell Host & Microbe showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Big thanks to collaborators Angela Jiang and Xiaofang Jiang NIH. sciencedirect.com/science/articl…

Large-scale CRISPR screening in primary human 3D gastric organoids enables comprehensive dissection of gene-drug interactions | Nature Communications share.google/Vt1ofQBjoABp81…