Here is our #insight on Jeremie Rosain et al’s recent study reporting anti-type I interferon autoantibodies & severe viral infections in incontinentia pigmenti: “Finding NEMO in the #thymus” with Moises Ocampo abt #NFkB signalling, immune #tolerance and #autoimmunity 👇

Last week's ICIS 🦋 @cytokinesociety.bsky.social #cytokines2024 meeting in Seoul was amazing! To celebrate, Science Immunology has just released a free sample collection of papers highlighting the immunology of #cytokines! Articles are free online to read for the next 6 weeks! bit.ly/SciImm_free

Very interesting review about kidney diseases caused by inborn errors of immunity, and their potential targeted therapies

Outcomes of #HCST in 18 patients with autosomal recessive C1q deficiency: link.springer.com/article/10.100…. Congratulations to all co-authors for their efforts in building a case series on the only soluble complement deficiency treatable with HCST!

Why do some patients present severe diseases when they meet Powassan, Usutu, and Ross River (arbo)viruses? Auto-antibodies to type I IFNs - again them ! Congrats to Adrian Gervais et al.

.Jeremie Rosain et al (hubs.la/Q02Vb-m60) describe the association btwn. anti-type I interferon autoantibodies & severe viral infections in patients w/ incontinentia pigmenti & heterozygous LOF NEMO variants. Ocampo-Godinez & Alex Yema Kreins 💙💛 discuss the study: hubs.la/Q02Vb-6b0

GWAS of non-syndromic cleft palate in 228 cases and 300k controls from Finland. The striking signal in chromosome 1 is driven by a noncoding variant near a transcription factor IRF6 disrupting an enhancer. The variant is 19 times more frequent in Finns than other Europeans.

On 21 November, Jacinta Bustamante, Bustamante Jacinta Université Paris Cité, Institut Imagine, INSERM, Casanova Lab , will give an online presentatione as part of our RESIST seminar series from 5 to 6 pm. The title is: Inherited TNF deficiency in humans resist-cluster.de/veranstaltung/…

1/ Delighted to share our review on Genetic Defects of Brain Immunity in Childhood Herpes Simplex Encephalitis (HSE), just out nature. Our expedition began in 2003, searching for monogenic defects underlying HSE (nature.com/articles/s4158…).

Abstracts due Dec 18th! Register for the International Society of Systemic #Autoinflammatory Diseases (ISSAID) Congress April 8-10 2025 in Paris, France! + a Young Investigator meeting on the 7th. TBD patient program elsewhere. #RheumTwitter #immunology issaid.org/issaid2025/ind…

Happy to announce the publication of our paper in Science Immunology. Here we describe the first patients with biallelic disease causing mutations in the LTBR gene encoding for the lymphotoxin beta receptor. Thread 1/10 science.org/doi/10.1126/sc…

1/ We report Immunity that the PD-1:PD-L1 axis promotes the development of B-cell memory and antibody responses in mice and humans. To our surprise, the pro-B-cell effect of PD-1 and PD-L1 is, at least partially, mediated in a B-cell-intrinsic manner. cell.com/immunity/abstr…

What Happens When Some Cells Are More Dad Than Mom (and Vice Versa)? Latest from us. Published today. News here cuimc.columbia.edu/news/what-happ… article here: nature.com/articles/s4158… O'Jay Stewart BogunovicLab and a huge international team thank you 🙏🏼 Columbia Children's Health Lipschultz Precision Immunology Institute

📢Join the Bukavu Scientific Days 🧬 📅Jan 8-9, 2025 🌍Genetic predisposition to infectious diseases 📍On-site in Bukavu & Paris or Zoom (register for link) Organizers: UOB-Université Officielle de Bukavu, Casanova Lab, @DMurhuLa142024 & Guillaume VOGT #Science #Health #Genetics #Disease #Infectious

We’re thrilled to announce our partnership with the International Alliance for Primary Immunodeficiency Societies (#IAPIDS) to launch the Journal of Human Immunity (JHI) Journal of Human Immunity! Stay tuned for groundbreaking, #OpenAccess research on #HumanImmunity! hubs.la/Q032Q5Zt0

I am thrilled to become the Editor of this new journal and grateful to both RUP and IAPIDS for their trust ! I also thank Megan Cooper who graciously accepted to become the Deputy Editor !

1/ We are proud of our former trainees and will be highlighting their accomplishments from time-to-time. First up is Satoshi Okada, appointed Chief Professor of the Department of Pediatrics at Hiroshima University in 2020 and advanced to Head of the Program of Medicine in 2024.

/ I was honored to accept the 2025 Novo Nordisk Prize from Novo Nordisk Foundation at today’s award ceremony in Copenhagen, Denmark. It was a wonderful day that included a tour of BioInnovation Institute, lunch at Novo Nordisk Foundation, and an evening award celebration and dinner.