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Ever felt your favorite gene has *more than one function* after perturbing it in many cell contexts? Today at #MLCB2021, I'll discuss automatic genotype-phenotype inference from high-dimensional gene perturbation data using sparse approximation: arxiv.org/abs/2111.06247 [a 🧵]

Scientists have solved the 3D structure of a three-protein complex that regulates the RAS signaling pathway & helps cancer cells with RAS mutations survive, suggesting possible ways that drugs can bind to it to inhibit the RAS pathway & block cancer growth broad.io/SMPnews

Nature research paper: Structure–function analysis of the SHOC2–MRAS–PP1C holophosphatase complex go.nature.com/3PbEfuw

Today in partnership with EMBL-EBI, we’re releasing predicted structures for nearly all catalogued proteins known to science, which will expand the #AlphaFold database by over 200x - from nearly 1 million to 200+ million structures: dpmd.ai/AF-22-TW 1/

Ever wondered if your favorite protein is amenable for targeting via degrader approach? Daniel Bondeson et al developed an elegant plug-n-play resource to profile the capacity for small molecule-mediated degradation of your POI through a panel of degron tags. nature.com/articles/s4146…

AlphaMissense, a tool by DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a new Science study. Learn more: scim.ag/49l

On knowing a gene: Distributional hypothesis of gene function Just as words derive meanings from context, genes can switch their roles with biological surroundings. Traditional gene annotations miss this Advances in transformers suggest a new perspective: gene functions as