As CKD resembles accelerated aging, patients with CKD may benefit from klotho-focused aging research. This article discusses a novel klotho variant, a procedure to synthesize and purify the protein, and and assay to test its bioactivity bit.ly/JASN0388

Christian Faul

As climate change escalates with increasing health impacts, healthcare must address its carbon footprint. This study demonstrated higher per patient carbon emissions from APD compared to CAPD and the consequent higher transport impacts bit.ly/JASN0361

Stephen McDonald

I was delighted to collaborate on this important study led by Yiting Li and Dr. Mara McAdams-DeMarco Center for Surgical & Transplant Applied Research, and with many others including Tanjala Purnell, PhD, MPH, FASN Roland Thorpe Sarah Szanton Dorry Segev

Dementia disproportionately impacts older minoritized adults with kidney failure. This study found residing in or receiving care at dialysis facilities in high-segregation neighborhoods was linked to higher risk of dementia diagnosis bit.ly/JASN0359

Deidra Crews, MD, ScM, FASN, MACP

The renal immune infiltrate observed in autosomal polycystic kidney disease contributes to the evolution of the disease. This study found activation of the cGAS/STING pathway contributes to ADPKD cystogenesis bit.ly/JASN0305

Evren U. Azeloglu

ESKD incidence has changed substantially in the past four decades. This Podcast discusses a recent study that found distinct patterns in ESKD incidence among patients of different age, sex, and racial groups bit.ly/JPOD0310

The transcription factor Grainyhead-like 2 (GRHL2) plays a crucial role in maintaining epithelial barrier properties of the renal collecting duct. This study suggests GRHL2 is a progression modifier, especially for cysts originating from collecting ducts bit.ly/JASN0353

The American Society of Nephrology launched Kidney TREKS to stimulate interest in nephrology. This article discusses how this program improves interest in nephrology in the short term and increases the number of individuals going into nephrology careers bit.ly/JASN0384

BIDMC

Spotlight on Diabetes: Check out these high-impact articles highlighting the research published in the ASN Journals. ow.ly/7Q1950RmbIu #diabetes JASN_News CJASN ASN Kidney360

The number of individuals with AKI receiving outpatient dialysis (AKI-D) is increasing. This Review discusses current trends in the incidence, risk factors, clinical outcomes, proposed management, and health policy landscape for individuals with AKI-D bit.ly/JASN0383

The severity of chronic histopathologic lesions on kidney biopsy is associated with higher risk of progressive CKD. This study used proteomic analysis to identify circulating proteins associated with chronic histopathologic lesions bit.ly/JASN0358

Anand Srivastava

Large increases in glomerular protein filtration increase risk of kidney functional decline and cardiovascular disease. This study found proteinuria modulated cell signaling in tubular epithelia and causes distinct patterns of remodeling and injury bit.ly/JASN0357

Kidneys are gatekeepers of systemic inorganic phosphate balance because they control urinary phosphate excretion. This study found depletion of renal Ip6k1/2 in mice not only altered phosphate homeostasis but also dysregulated other kidney functions bit.ly/JASN0303

The distal convoluted tubule (DCT) comprises two subsegments with different functional and molecular characteristics. This study found transcriptomic analysis of an enriched rare cell population clarifies the function and classification of distal cells bit.ly/JASN0297

Proteins and metabolites play crucial roles in various biological functions. This study demonstrates that integration of the proteome and metabolome can identify functions of pathophysiologic importance in kidney disease bit.ly/JASN0343

Sushrut Waikar Morgan Grams

The American Society of Nephrology Journal editors recently created a new ASN Journals’ Editorial Board. This broader editorial board includes editors who work across all three journals to support JASN, CJASN, and American Society of Nephrology360. For more information, visit bit.ly/ASNEdBoard

The link between the histology of kidney transplant rejection and the types of infiltrating immune cells is not well charted. This study found the estimated immune cell composition of kidney transplants is ill related to Banff-defined rejection categories bit.ly/JASN0350

Proteinuria predicts accelerated decline in kidney function in CKD. This study found in conditions with proteinuria, uPA-plasmin generates anaphylatoxins in tubular fluid and promotes downstream complement activation sensitive to amiloride bit.ly/JASN0312

The mechanism for renal cyst formation is unclear. This study shows Pkd2 deletion in embryonic AP was sufficient to cause severe PKD with progressive elimination of α-intercalated cells, supporting a newly found cellular phenotype of patients with ADPKD bit.ly/JASN0309

Hyperglycaemia influences the development of glomerular endothelial cell damage. This study found Set7 regulates the phenotypic EDMT switch & suggests that targeting the lysine methyltransferase could protect glomerular cell injury in DKD bit.ly/JASN0345