Excited to share recently published work with Kelsey Wheeler and a great team looking into how mucins influence oral microbial communities!

Incredibly proud to be a part of this team!

We have some big news - we'll be in sunny LA on May 17 to present at @ASGCT's annual conference! We're so excited to share what we've been working on and present some really incredible data at #ASGCT23. Check out our press release for more details: keloniatx.com/news/

Excited to attend #ASGCT23 next week with the KeloniaTx crew! Please reach out if you’d like to meet up

#ASGCT2023 News: KeloniaTx Lentiviral Particles May Solve In Vivo Delivery Hurdles for CAR T Cells genengnews.com/gen-edge/asgct… via Genetic Engineering & Biotechnology News

How I know DC is home now: I ordered a tea and was brought a beverage sweeter than any soft drink on the menu. This is the correct response and I will not be taking questions at this time

More healthcare gold. Now how to drive reforms that do away with this dark humor. No Patient Left Behind

Can confirm - I used to get off the T early because it was faster to walk… What doesn’t make the headline is that wait times were often 10-15 minutes before getting on a standing room only train going slower than walking speed

There’s a frequent perception among recent entrants to drug discovery world that if we could just find drug candidates faster, this will be a useful accelerant to the overall process. The issue is: this thinking is mostly (but not entirely) incorrect. 🧵 1/

Big day for the team!

So much wrong with this it’s hard to know where to start. Two sets of student loan borrowers are currently getting relief. The first: public servants, like members of the military. Under a law signed by President Bush, they get loans cancelled after ten years of service. 1/

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma biorxiv.org/cgi/content/sh… #biorxiv_immuno

Library-based single-cell analysis of CAR signaling reveals drivers of in vivo persistence biorxiv.org/cgi/content/sh… #biorxiv_immuno

Excited to share some of my PhD work was pre-printed! Using single-cell sequencing, we took a deep look at a library of CAR signaling architectures to try to identify signal-intrinsic drivers of CAR-T function🧵👇 Michael Birnbaum Koch Institute at MIT MIT Dept of BE biorxiv.org/content/10.110…

It’s been really cool to see the confluence of technology development and molecular insights that have enabled such detailed studies of viral molecules directly on viruses, performed safely and efficiently. Can’t wait for future progress in this space

Lots of good answers to this, but for me it has to be high-quality single-molecule protein sequencing methods. From basic science to the clinic, there’s so much we could learn from knowing what’s going on at the protein level in and out of cells

Um..🤯. Freeze dried tissue preserves chromatin for centuries! “…we dehydrated the tissue first. The architecture was fine….Ran over it with a car, had a former Astros starting pitcher throw a fastball at it, fired a shotgun at it. Still fine.”

Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells biorxiv.org/cgi/content/sh… #biorxiv_immuno

Excited to see some movement on understanding the human thymus, and for everything Brooke Huisman will build on from here 🚀

These are the days that make the long hours worth it. Excited to see a technology I invented take this big step toward benefitting patients. Grateful to the whole team at Kelonia for building what was once just cool tech into a real drug that could bring CAR-T to everyone.