Spike activates HIF-1 > TGF-β > immune checkpoint proteins > suppresses Th & Tc cells. "Spike [.] triggers activation of immune evasion machinery similar to the one operated by cancer cells & most likely could support malignancies" trialsitenews.com/a/sars-cov-2-s… frontiersin.org/journals/immun…

UK NICE: Clinical Knowledge Summary (CKS) on ME/CFS has been published. It summarises key points and provides guidance for clinicians: cks.nice.org.uk/topics/myalgic… Science for ME forum discussion has raised significant issues with the document. s4me.info/threads/nice-c… #MEcfs #PwME

UK Government: Publication of the long delayed Delivery Plan for ME/CFS has been delayed again. Advocacy group #ThereForME give an update, saying they have been involved in the final stages and there is a plan, but no new funding. substack.com/@karenlhargrav… #MEcfs #PwME

2/ "In both ME/CFS patients and LCS [Long Covid Syndrome], an altered gut microbiota has been observed. Some studies have also reported reduced bacterial diversity and abundance compared to healthy individuals." #MEcfs #LongCovid

2/ "This systematic review aims to evaluate and summarize recent evidence on nutrient supplementation and diet-based interventions in patients with ME/CFS sourced from clinical trial registries and article databases." #MEcfs #PwME

Spain: Long Covid recognized as a chronic disease "It is estimated that ... between 1% and 2% of the population [suffer from Long Covid], equivalent in Spain to between 450,000 and 900,000 people." El Pais elpais.com/sociedad/2025-…

👨‍🔬 👩‍🔬 We always want to support early-career researchers with the next breakthrough in #MECFS research 🧪 That’s why we’re offering researchers free ME-CFS samples to help your projects, PhDs & publications Send your application by 31 July 🔽 bit.ly/MECFS-samples

Lull: Designing Crip Pacing Technologies for Rest dl.acm.org/doi/abs/10.114… "Commercially available fitness tracking technologies are currently being “misused” to manage these conditions [long COVID and ME/CFS]." #LongCovid #MEcfs

Blood parameters differentiate post COVID-19 condition from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia Free fulltext: sciencedirect.com/science/articl… #LongCovid #MEcfs

From Australia: Distinct white matter alteration patterns in post-infectious and gradual onset chronic fatigue syndrome revealed by diffusion MRI Free fulltext: nature.com/articles/s4159… #MEcfs #CFS

New from Canada & Norway: SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis …nslational-medicine.biomedcentral.com/articles/10.11… Funded by the Open Medicine Foundation Canada Open Medicine Foundation Canada Open Medicine Foundation #MEcfs #CFS #PwME

Actively protective combinatorial analysis: A scalable novel method for detecting variants that contribute to reduced disease prevalence in high-risk individuals sciencedirect.com/science/articl… Image is from the Science for ME weekly update #MEcfs #CFS

From Denmark: Increased Risk of Post-Acute Sequalae of COVID-19 in Patients With Immune-Mediated Inflammatory Diseases ghadvances.org/article/S2772-… Image is from the Science for ME weekly update #LongCovid #PASC

From Brazil: Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms nature.com/articles/s4159… Image is from the Science for ME weekly update #LongCovid #PASC

From Italy: "identification of significant hypometabolism and EEG slowing in anterior brain regions in patients with persistent subjective cognitive decline after mild COVID-19" nature.com/articles/s4159… Image is from the Science for ME weekly update #NeuroPASC #LongCovid

Very interesting results from Open Medicine Foundation Canada and Open Medicine Foundation regarding biomarker AND therapeutic target in #MECFS! Link to paper ⬇️

This is 1 of 6 Dr. Alain Moreau Papers that he mentioned in a recent interview. mecfsdiagnosticbiomarkers.substack.com/p/11-micrornas… Thank you for the tag zedsrigil

M.E patients exhibited reduced membrane-bound SMPDL3B on monocytes & lymphocytes, particularly in those with high circulating levels of soluble form. Vildagliptin or Saxagliptin restores SMPDL3B membrane binding, potentially dampening TLR4 inflammation & restoring immune balance.