A 5-year observational study of ~12,000 individuals with obesity taking GLP-1 drugs (without diabetes) with propensity matched controls A significant reduction of all-cause mortality (HR 0.23, 95% CI 0.15, 0.34) …ubs.pericles-prod.literatumonline.com/doi/10.1111/do…

Other outcomes assessed. Significant reductions of ischemic heart disease (IHD), stroke, heart failure, arrhythmias, atrial fibrillation, acute and chronic kidney disease, allergic reactions

Diego del Alamo Also, important to keep in mind, AlphaFold3 uses templates (PDB) input. It would be good to redo this analysis once the code it out... 🙃 and see if the diffusion module can sample alternative conformations, once the template is removed.

This is a remarkable chart. Major reduction in mortality among those taking GLP-1 (i.e. ozempic) vs (statistically) matched group In General: for every 4 ppl not taking GLP-1 who died during 5 yr follow-up, only 1 on GLP-1 died Not randomized control study but very convincing

Lack of diagnostics is a key barrier to tackling antimicrobial resistance! Please read our The Lancet Microbe comment: thelancet.com/journals/lanmi…

The result is a catalog of sb-eQTL that is highly enriched for loci associated with complex sex-biased traits and diseases such as body height and multiple sclerosis. Here’s an example of an eQTL only in males that colocalizes with GWAS signal for MS (5/6)

Super excited to see my first preprint from grad school come out! Check out the 🧵 for some new discoveries in how biological sex impacts the transcriptome 🧬

The Kruskal-Wallis test is a non-parametric method used to determine if there are statistically significant differences in the distributions of three or more independent groups based on ranks. Unlike ANOVA, it does not assume a normal distribution, making it versatile for

Potential implications of using locally validated risk factors for drug-resistant pathogens in patients with community-acquired pneumonia in US hospitals: A cross-sectional study. ✅ Just Accepted 🔗 bit.ly/3Z8M2kH

Evaluating the normality of your data is crucial in statistical analysis, as many techniques assume that the data follows a normal distribution. The QQ plot (Quantile-Quantile plot) is a simple yet powerful tool to visually assess this. ✔️ Improved Model Accuracy: Properly

Exciting discovery: CSF flow isn't confined to the brain and spinal cord—it also extends to peripheral nerves! Science Magazine science.org/doi/10.1126/sc… Groundbreaking research from UF Health FLORIDA #neurotwitter #neuroscience #AcademicChatter

Waste management won’t solve the plastics problem — we need to cut consumption go.nature.com/4dNdzwo

Sharing this webinar again from Dec. 2023 on ME/CFS Physiology Webinar, 6 of 8. ~ 6:00 min Prof. Michelle James (Stanford) on some eye opening findings from PET scans: youtu.be/Y5AvIGvjyO4?si… #MECFS #Pathophysiology #BoneMarrow #SalivaryGlands #Microglia 🧠 #Muscles #TSPO

Michal Tal, PhD Anne Maitland, MD This is pretty bleak given that COVID produces an almost 50% increase in the risk of GERD webmd.com/covid/news/202…

Someone may now not test positive for #COVID until they’ve already been feeling sick for days so serial tests over several days is now recommended. time.com/7018565/do-at-…

Covid vaccines saved more than lives, it added trillions in economic value! Covid-19 vaccination provided >US$5 trillion in value globally through December 2021, with a conservative benefit-cost ratios of 14 gh.bmj.com/content/bmjgh/…

Mitochondrial double-stranded RNA homeostasis depends on cell-cycle progression life-science-alliance.org/content/7/11/e… A fascinating piece of work from Thomas MacVicar Lab.

Diffold, which uses AF2 fine-tuned w diffusion to sample multiple protein conformations, got renamed to UFConf and performs about as well as AlphaFlow and much better than AF-cluster, MSA subsampling, etc biorxiv.org/content/10.110…

Also this paper contains more evidence that AF3 sucks at conformational sampling, most likely for reasons explained here x.com/sokrypton/stat…

Ian Weissman, DO Known for years. It’s much easier to get one of these and you’ll detect it before you even start feeling symptoms.