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FGF21 analogs reduce liver steatosis and fibrosis in patients with MAFLD/MASH. Our new paper provides insight into the mechanisms for these effects: cell.com/cell-metabolis… OU Health Harold Hamm Diabetes Center OU Health

🧵Chronic inflammatory diseases and autoimmune diseases skew female. Can the relevant pathophysiology of diseases like endometriosis (highlighted in the NIH NAMs report) really be replicated in mice (or even baboons)? The peritoneal macrophage environment in mice - so different.

🧵As a scientist who lived through 9 endometriosis surgeries, 2 bouts of breast cancer (including TNBC), and took crazy crazy drugs that did not work, I vote for "Move Over, Mice". We need to humanize biomedical research, for the PARTICULARS that do not translate.

Michal Tal, PhD Daniel Litt Chronic effects of lifetime loads of acute infections define each of us today and our future life, most important answers are truly simple and very logical.

Michal Tal, PhD Daniel Litt There's going to be a ClinVar/OMIM size database of "acquired" autoantibody-induced traits - tens of thousands of them - and only a handful are known. Most of the actionable mechanisms everyone wants to find for chronic disease, ageing, etc await discovery in this datatype.

Michal Tal, PhD Daniel Litt Also pluckable - most things in the space of maternal-fetal drug or toxin transmission and its effects on embryonic development. This ranges from OTC medications to prescriptions to recreational drugs to environmental toxins.

Exciting to share our paper on genetics of #longCOVID with Vilma Lammi, Tomoko Nakanishi, Hugo Zeberg and many others! nature.com/articles/s4158…  HiLIFE_Helsinki University of Helsinki Mass General Brigham Research

A new Science #Immunology Review examines #neuroimmune crosstalk and highlights the potential for #immunotherapies for Alzheimer’s disease and neuromodulators to treat asthma and food allergy. scim.ag/4dkHAV4

High-throughput magnetic separator for purifying IgG from 500 clinical samples/day. Printable design: a360.co/43naWNT

Human chronic inflammation is orchestrated by spatially restricted inflammation-activated DCs biorxiv.org/content/10.110…

Here in the Research Directions Workshop in Sydney, after the World Congress of Endometriosis, there is a lot of discussion about including adenomyosis (hooray for that!). This new paper from Dr Varsha Jain offers a much needed next step in diagnosis. fertstertscience.org/article/S2666-…

A novel low-volume multiplex immunofluorescence assay was developed to simultaneously measure all nine antibody isotypes and subtypes in human fluids, including breastmilk. Learn more about the method in The JI: ow.ly/nAJ450VWjh8

A virus best known for causing cold sores may dramatically increase the risk of Alzheimer’s in people with a specific gene variant. New evidence suggests herpes reactivation in the brain may trigger the destructive changes seen in the disease. dlvr.it/TKzR1C

The researchers also found people who received antiviral treatment for Herpes (HSV-1) had roughly a 17% lower risk of developing Alzheimer's disease compared to those who were untreated. sciencealert.com/new-link-conne…

Led by Ya'el Courtney, PhD and out today in Nature Neuroscience: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread rdcu.be/eoaSY

This is why science funding matters. We uncovered a hidden signaling system in the brain—one that responds to maternal environment, even to drugs like LSD during pregnancy. It took 5 years, a brilliant team, and public funding to get here. Out today in Nature Neuroscience: 🧵👇

To close #WomeninPathology Month, we are featuring one of the WiP Co-Leaders, Dr. Francisco J. Carrillo-Salinas. We want to celebrate his recently accepted a position in the Tal Research Group at Massachusetts Institute of Technology (MIT) and his faithful support of women in STEM. Full bio bit.ly/38Jufby