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Delighted to get this out!we describe bitopic binding mode to the dopamine 3 receptor, including a reorganization of TM1 that generates a unique site that could be exploited to develop selective molecules. Tremendous effort from Sandra Arroyo Urea Angela nature.com/articles/s4146…

Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function! Great collab w Julian Langer lab and Seeger Lab. Out in Nature Communications doi.org/10.1038/s41467…

Cryo-EM is a bit of an imaging miracle. We collect 2D images with stupid amounts of noise. We don’t know what we’re looking at, or from which way. Yet some how we can churn it over and get to see (actually see) how life works on molecular scales in 3D. How?

The γTuRC saga goes on! This time, we used cryoEM to describe how CDK5RAP2 helps nucleating microtubules by activating the γTuRC nucleator. Another tour de force led by Marina Serna and Fabian Zimmermann and a fun collab with Jens Luders @LudersLab.bsky.social IRB Barcelona. authors.elsevier.com/c/1jpyq_Yv6zvB…

First data from my PhD out now in preprint! Turns out that the orphan SLC45A4 is a polyamine transporter involved in pain signalling, that contains a novel autoinhibitory plug domain biorxiv.org/content/10.110…

From our neighbor next door!

I'am thrilled to share our latest paper, revealing how specific lipids play a critical role in the HIV neutralization process: pubs.acs.org/doi/10.1021/ac…

A reminder that our new lab at Molekylærbiologi - Molecular Biology has a fully funded postdoc position available. Our group integrates biochemistry, cryoEM, and single-molecule imaging to explore the mechanisms of DNA repair complexes. 🧬🔬 sites.google.com/view/alconlab/… Please share with your colleagues!

🔴Igor Tascon and Iban Ubarretxena Iban Ubarretxena are co-corresponding authors of a paper pubished in Science Advances "Structural basis for regulation of a CBASS-CRISPR-Cas defense island by a transmembrane anti-σ factor and its ECF σ partner" Congrats!

We're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out! We already have two open, fully funded positions: 🔬- Postdoc: cnio.es/en/empleo/post… 🧪- Senior Scientist: cnio.es/en/empleo/rese…

It is finally out! Have a look on how bacterial ESCRT-III protein Vipp1 progresses from 2D to 3D to carry out membrane remodeling. Honored to have contributed here!

Congrats Rafa! 💪🏾💪🏾

5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬 They're fully funded for 4 years. Salary: 42,800 euros gross per year. See details below:

Great opportunity to work with an amazing PI, apply!!

Find our fresh peer-reviewed report on “Molecular Architecture of Synaptic Vesicles” here: pnas.org/doi/10.1073/pn… We analyzed synaptic vesicles in neurons and in isolation to describe molecules on their surface. 🧠💥🔬

Our paper on the reaction cycle of the human dicarboxylate transporter NaDC3 finally came out in NSMB.com .

📢 Javier Garcia Nafria receives €2 million from the ERC program to find new mechanisms to control #inflammation . #ReSolVer will study the end phase of #inflammation , and will provide strategies for the development of new anti-inflammatory drugs. Congrats! UCC unizar #ReSolVer

We have a couple of fully-funded PhD opportunities available, with HetSys CDT and MIBTP Doctoral training Centres. See here for more information: stansfeldresearchgroup.wordpress.com/welcome/availa…

Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron detector, now online Science Advances. science.org/doi/10.1126/sc… . A collaboration with Gatan Microscopy, @GeorgRamm, and Ramaciotti Centre for Cryo EM.