Tweetorial 👇👇👇 NEJM 24.05.18

Do not use isotope bone scans to identify myeloma-related bone disease in people with a plasma cell disorder suspected to be myeloma.

Most cases of Restless legs syndrome are idiopathic. Associated conditions: Low iron stores Uremia Neuropathy Spinal cord disease Pregnancy

Comparison of gout and calcium pyrophosphate deposition disease

This trial shows an increased rate of events with rivaroxaban as compared with warfarin in patients with antiphospholipid syndrome. bloodjournal.org/content/early/…

Causes of Hypokalaemia without hypertension: ▪Diuretics ▪GI loss ▪Renal tubular acidosis (type 1 & 2) ▪Bartter's syndrome ▪Gitelman syndrome

Management of statin myopathy

Systemic embolization occurs at a frequency of approximately 0.7% to 1% per patient per year in patients with mechanical valves who are treated with vitamin K antagonist. In comparison, the risk is 2.2% per patient per year with aspirin and 4% with no anticoagulation.

What is the preferred anticoagulation for antiphospholipid syndrome (APS) with VTE?

Common side effects of Rifampicin: ■Potent liver enzyme inducer ■Hepatitis ■Orange secretion ■Flu-like symptoms

"If you define success in terms of winning and losing, you’ve already lost" - Adam Grant

Causes of secondary hyperparathyroidism

Dose dependence of thiazide-induced side effects " bendrofluazide in relation to daily dose "

Peripheral neuropathy: differential STAGLAND: 👉Sarcoid 👉Thyroid 👉Amyloid 👉Guillian-Barre 👉Lead 👉Alcohol 👉Nutritional 👉Drugs/Diabetes

Thiamine deficiency manifesting as Wernicke encephalopathy : ● Nystagmus ● Ophthalmoplegia ● Ataxia ● Confusion

Internal medicine Up to 70% will not have the classic triad on presentation (and MRI not very sensitive either). Diagnose based on response to empiric IV thiamine (500mg q8h)

Long-distance Travel & VTE prophylaxis #ASH18 Guidelines

Causes of unintentional weight loss

Time to positivity of HIV diagnostic tests

Approach to perioperative management of patients on warfarin undergoing major surgery