IJMSC Insights between Sue Britt & E Morrison-Banks: "[A]cross the board, not just in #MultipleSclerosis care, [we need] to have open & honest conversations [about #abuse/#neglect]. Are there any points [where] we can intervene [to prevent it from] becoming worse?"

"[W]e demonstrate significant circulating metabolome alterations in [pts with RR #MultipleSclerosis] as result of #ocrelizumab treatment...metabolites involved in lysophospholipid pathway were reduced significantly, which was associated with improvement in...disability measures."

"#Age is relevant in determining disability progression in MS. [Pediatric-onset #MultipleSclerosis] shows less steep increase in EDSS scores...effect of PIRA in accelerating #EDSS progression is less pronounced in POMS than in [adult-onset] & [late-onset]" doi.org/10.1007/s00415…

"[F]indings provide new insights to explain [#MultipleSclerosis] geographic variability across [#France]...results emphasize crucial role of #environmental exposures associated with geographic location of birth when examining [MS] risk factors" doi.org/10.1016/j.msar… Department of Brain and Behavioral Sciences UNIPV

"[C]onsistent #microbial signatures [are]associated with [#MultipleSclerosis] across studies. Prevotella is significant #biomarker in diagnosis in individual project analysis. Faecalibacterium & Actinomyces are assoc with diagnosis..." doi.org/10.1186/s13073… UConn Health UConn

"These findings provide more insights into mechanisms behind [grey matter] #lesion formation & progression & underscore putative #therapeutic potential of checkpoint molecules in mitigating pathological progression in both [white matter] & GM." doi.org/10.1093/brainc… NIN

"100 [indivs w/] #MultipleSclerosis, rate of amyloid-β plasma biomarker positivity was ~half rate in 300 nonMS matched on age, sex, apolipoprotein E proteotype & cognitive status....results support that MS is associated w/ reduced #Alzheimer disease risk." doi.org/10.1002/ana.27…

"Youth with [#pediatric-onset #MultipleSclerosis] were more likely to have...low childhood [#socioeconomic status], reflected at household level as lower maternal education & neighborhood level as higher scores on...disadvantage index." doi.org/10.1212/NXI.00… Boston Children's

"12 wks of intermittent [#calorie restriction] decreases serum leptin, proinflammatory adipokine with potential pathogenic role in [#MultipleSclerosis]. [Also], iCR changes peripheral immune cell & lipid profiles & may improve #cognition." doi.org/10.1136/jnnp-2… Piccio Lab

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The Hello Brain! exhibit The Crick has #neurons knitted by Crick colleagues, friends & family. crick.ac.uk/whats-on/exhib… #NeuroArtFriday #Knitting

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"Comorbidities are more prevalent among Brazilian individuals with #MS than in the general population and are associated with disease progression." Identifying these and applying evidence-based strategies for their management can improve clinical outcomes. doi.org/10.7224/1537-2…

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