The lab during paper revisions

Happy to share our newest article Ribbe Hu Labs, published in Science Advances ! If you're interested in why life on Earth didn't die out billions of years ago, dive in! Also, my first paper presenting thread 🧵 science.org/doi/10.1126/sc… #ScienceAdvancesResearch

We are proud to announce a $50M gift from Charlie Dunlop, founder of Ambry Genetics. Our school will now be known as the Charlie Dunlop School of Biological Sciences. This gift will significantly impact our school and the broader scientific community. #DunlopSchool Frank LaFerla

This is the most important video you'll see today!

Our years of work on nitrogenase assembly paid off! So proud of this paper, which demonstrates the heterologous expression of an active nitrogenase. Thanks to everybody involved for a great team effort! Nature Catalysis, Ribbe Hu Labs, UCI Charlie Dunlop School of Biological Sciences, UCI Chemistry doi.org/10.1038/s41929…

Congrats for finally demonstrating the expression of metallocluster replete nitrogenases in E. coli. That's a fantastic advancement!

Our latest work on a #nitrogenase-like enzyme, the methylthio-alkane reductase which surprisingly also contains large nitrogenase metalloclusters, the P-cluster and the [Fe8S9C]- (L)-cluster is now online: doi.org/10.1101/2024.1… Have a look at the 🧵 by @AnaLagoMaciel.

Our story made the cover! Really proud of it. Thank you so much Nature Catalysis for supporting our work! Nature Catalysis, Ribbe Hu Labs, UCI Charlie Dunlop School of Biological Sciences, UCI Chemistry nature.com/natcatal/volum… nature.com/articles/s4192…

The Department of Molecular Biology and Biochemistry in the Charlie Dunlop School of Biological Sciences at UC Irvine invites applications for a tenure-track Assistant Professorship in Structural Biology and Biochemistry: recruit.ap.uci.edu/JPF09353

Congrats Leo & Joe! This is awesome!

Allow me to introduce to you ... The bucket!

I'm truly excited to announce our new publication in nature unraveling a central picture of the Methyl-coenzyme M reductase (MCR) activation machinery and it's strong ATP dependency - kudos to Anuj Kumar for the fantastic illustration! LINK: nature.com/articles/s4158…

wondering how does this species survive in the wild.

Excited to share our latest work highlighting the crucial role of belt-sulfur mobilization in nitrogenase catalysis. A big thank you to everyone who contributed to this effort! Chem Catalysis, Ribbe Hu Labs, UCI Charlie Dunlop School of Biological Sciences, UCI Chemistry cell.com/chem-catalysis…

Our second paper was published online within the same week 😊! Thanks everyone for their hard work! Science Advances, Ribbe Hu Labs, UCI Charlie Dunlop School of Biological Sciences, UCI Chemistry Heterologous synthesis of a simplified nitrogenase analog in Escherichia coli | Science Advances science.org/doi/10.1126/sc…

You may ask: “why study ancient enzymes? Who cares what life looked like 3 billion years ago?” Because evolution may hold answers to problems we still struggle with, and it can guide our efforts. New paper from our lab! 🧵

Using spectroscopic and structural approaches we gained new insights into the role of #ferredoxins in N2 fixation. Just published in ChemEurJ: Chemistry - A European Journal: doi.org/10.1002/chem.2…! Great work by Holly Addison and fantastic excellent with Antonio J. Pierik.

Congratulations to Bryan Neumann from our collaborator Shane Gonen’s lab on receiving the Barbara K. Burgess Postdoctoral Fellowship Award — a well-deserved honor! Shane Gonen Ribbe Hu Labs UCI Charlie Dunlop School of Biological Sciences

Great talk by Joe Rebelein yesterday evening at the MoTEC 2025 at long beach! Congratulations to the EMBO young investigator lecture! Much deserved 👍

Ribbe Hu Labs Lab reunion at the Molybdenum Tungsten Enzyme Conference #MoTEC on the Queen Mary in Long Beach, CA. With great talks by Markus and Yilin.