A huge congrats to my graduate student Andy Heindel for publishing his work on developing PACCE for global quantification of protein-RNA binding activity in live cells. We thank our collaborators Markus Hafner NIAMS & Thurl Harris UVA Pharmacology. disq.us/t/4jhbf7b

Excited to be in Paris for the GERLI Lipid meeting! What a beautiful city. See you soon lipid friends! 😊 #LipidTime gerli.com/congres/welcom…

Great to see this exciting story out w/Bristol Myers Squibb. Novel DGKα/ζ inhibitors discovered via phenotypic HTS promote robust T-cell antitumor immunity. Notably, target ID was enabled using promiscuous PAL probes, where we found hits induce membrane translocation science.org/doi/full/10.11…

First research paper led by our group is out in Angewandte Chemie! Introducing new tools for #SARSCoV2 & #colorectalcancer protease sensing. Thanks, American Cancer Society for funding, Anna Capasso for patient samples, & SUBRATA PANDIT for a heroic effort. Read more:tinyurl.com/BarProt

Thank you Ku-Lung Hsu for the invitation to give a talk at UT Austin. It was lovely to catch up with old friends and meet new ones! I had a blast.

Congrats to my students Myungsun Shin, Tim Ware, and Miaomiao Chen on their paper in PNAS describing LKB1-AMPK regulation by endocannabinoid biosynthetic enzymes. Great collaboration with the Lichtman, Leitinger, and Harris labs. pnas.org/doi/10.1073/pn…

nature.com/articles/s4158… Delighted to share our recent work. We developed an enhanced chemoproteomic workflow to determine PAL probe interaction sites in cells, enabling ID of diverse binding pockets, providing evidence of their chemical tractability & more w/ForliLab & Bristol Myers Squibb

Excited to share the final version in Nature Chemical Biology. Lots more mechanistic insights & characterization, including our inhibitors disrupt PPIs with mTOR components & induce lysosomal degradation of SLC15A4, & more. A promising target for autoimmune conditions. nature.com/articles/s4158…

Integration of DOS with PAL-based chemoproteomics from the Cravatt Lab. Further highlights the power of stereochemically matched probes to ID ligandable proteins. biorxiv.org/content/10.110…

Apply now for the 2025 Mark Foundation Emerging Leader Award! Grants are awarded to early-career investigators in US and Canada for projects addressing unmet needs in cancer research. Deadline to apply is April 29. For more information, please visit bit.ly/3Iw678s

Had tons of fun hearing good science at the 2024 Drug Discovery Chemistry meeting and also hanging out with friends Nir London, Ku-Lung Hsu Michael Erb Fleur Ferguson, Luke Lairson, and not pictured but also Brent Martin, Chris Parker Mia Huang 黃雪兒 !

We're honored to host Yi Tang of UCLA Chem & Biochem, this year's Vista Chemical Company Regents Endowed Memorial Lectureship in Organic Chemistry speaker.

A big congratulations to Dr. Homan Rick Homan!!! Fabulous job! Rick is our 2 of 2 first Ph.D’s! Thank you Michael Erb WisemanLab Carsten Schultz Lab and Pat Griffin for serving on his committee

I'm very excited to share the news of my promotion. Much of the credit goes to the trainees that drove the research forward, and the invaluable mentorship that I received along the way from Michael Hecht, David R. Liu, Kapoor Lab, my Princeton colleagues, and many others!

Awesome news! Congratulations KleinerLab!!

Upcoming webinar with GlycoNet investigator Dr. Lara Mahal! Prof. Lara K. Mahal #glycotime #glycomics

After 11 great yrs Duke University, the Hargrove Lab is starting a new chapter Chemistry at UofT & U of T Mississauga ! We are deeply grateful for everyone at Duke who has supported us, esp. in Duke University Chemistry Duke Department of Biochemistry, and the NC RNA & ChemBio communities💙 Look for more on our Canadian adventures soon!🇨🇦

We are excited to announce that Kurtis Carsch is joining our department! cm.utexas.edu/news/entry/kur…

Congrats to my team UT Austin Chemistry for developing sulfonyl-azoles as tyrosine-reactive electrophiles. Thank you to The Welch Foundation for the support. …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cb…