Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation pubmed.ncbi.nlm.nih.gov/38228690/

New paper: we developed Methylation Screening Array (MSA)–a scalable tool to dissect DNA methylation in large cohorts. By profiling 5mC & 5hmC, we uncover trait- and cell-type-specific cytosine mod signatures across tissue, aging. doi.org/10.1016/j.xgen… #Epigenetics #EWAS #5hmC

DNA methylation goes spatial! Introducing Spatial-DMT: a technology that co-profiles DNA methylation and transcriptome in the same tissue section. A fantastic collaboration with Wanding Zhou lab. Kudos to Chin Nien Lee Chin Nien Lee and Hongxiang Fu! biorxiv.org/content/10.110…

Spatial-DMT is now published in nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with Wanding Zhou lab. Big congrats to Chin Chin , Hongxiang Hongxiang Fu and team! nature.com/articles/s4158…

Excited to share our latest work, “KnowYourCG: Facilitating base-level sparse methylome interpretation” in Science Advances! Our computational framework enables efficient functional enrichment for DNA methylation data from diverse assay platforms science.org/doi/10.1126/sc…