Aline Charabaty, MD, FACG, AGAF #MondayNightIBD Takeda JanssenUS David Schwartz Amy Lee Lightner, MD David Schwartzberg, MD Stefan Holubar MD MS Seb Antonino Spinelli Fernando Gomollón Bram Verstockt Gianluca Pellino Julio Mayol Dr Feza Remzi Paulo G. Kotze Andres Yarur Daniel J. Stein This figure summarizes the problem after seton placement, demonstrating the intersection of setons, definitive surgery and advanced Rx. Would be nice to do a 6 way RCT (LOL). Recent studies however have started to unravel this dilemma. More to come

#MondayNightIBD Aline Charabaty, MD, FACG, AGAF Takeda JanssenUS David Schwartz Amy Lee Lightner, MD David Schwartzberg, MD Stefan Holubar MD MS Seb Antonino Spinelli Fernando Gomollón Bram Verstockt Gianluca Pellino Julio Mayol The PISA II Trial has shown the value of early surgery in CD anal fistula (better clinical and MRI healing). This approach parallels a changing landscape in the medical (think of Top Down and the PROFILE Trial results) and surgical management (think of the LYR!C Trial) of CD.

#MondayNightIBD Aline Charabaty, MD, FACG, AGAF Takeda JanssenUS David Schwartz Amy Lee Lightner, MD David Schwartzberg, MD Stefan Holubar MD MS Seb Antonino Spinelli Fernando Gomollón Bram Verstockt Gianluca Pellino Julio Mayol 22y/o w crohns ileitis in endo remission on IFX, develop perianal abscess & fistula. Abscess drained & #seton placed in mid-transphincteric #Fistula . 
3 months later, he has minimal drainage, no pain
IFX TL 16, no ATI
#MondayNightIBD what’s the next step?
(🔑d/c =remove)

Tofacitinib before surgery for UC associated with 3-fold risk of VTE. Read more in this month's #DCRJournal : bit.ly/3xy3HXm

Tara Russell Scott R. Steele Amy Lee Lightner, MD Stefan Holubar MD MS Jeremy Lipman Sudeep Banerjee Tracy Hull Cleveland Clinic

Join us at #ASCRS24 for a symposium titled, 'Anastomotic Leak Consensus,' unveiling the findings of CoReAL. This framework has the potential to destigmatize leak reporting, reduce care delays, and enhance patient outcomes. Save the date: ascrs24.eventscribe.net/index.asp?sess…

Looking forward to highlighting how to discuss risks of advanced therapies with patients. Hope to see you there! #IBD #GITwitter

Very timely with Ailsa Hart visiting us WashU Gastroenterology and highlighting the #TOpCLASS classification in her keynote talk at #WUIBDCME24 . Great collaboration with Seb IBDHull As Seb said, all IBD units should start using this to classify the patient's disease journey in pfCD.

The New classification of pCD is a vital step progressing research in personal fistula in CD . Suggest all #IBD units use this .

The original paper pubmed.ncbi.nlm.nih.gov/35325623/

An analysis of the use of the #TOPCLASS classification 👇

#TOpCLASS classification highlights the dynamic nature of perianal fistulizing #CD over time, however, our ability to predict transitions between classes remains limited and requires prospective assessment. Matthew Schroeder Parakkal Deepak MD, MS, FACG Seb
academic.oup.com/ecco-jcc/advan…

3D #Pouch Reconstruction: A Breakthrough in Visualizing #IPAA Anatomy and Pathology Stefan Holubar MD MS Florian Rieder Miguel Regueiro

academic.oup.com/ecco-jcc/advan…

⁦Phil Tozer⁩ giving great talk on #stemcells in #perianal #crohnsdisease …real world registry showing positive outcome in >70% but phase 3 negative…next steps? Creating novel future products!

⁦Stefan Holubar MD MS⁩ great talk about proctectomy for #perianal #crohnsdisease challenge of closing defect…omental flap or gracilis can be helpful

Excited to be in London for a great #inflammatoryboweldiseaseawareness conference and even a morning walk to #multidisciplinary conference on #crohnsdisease and #ulcerativecolitis with Peter.irving at St Thomas Hospital

Just the appetizer to the main course tomorrow of #IBDCME IBD WUSTL WashU Gastroenterology headlined by Florin M. Selaru Johns Hopkins Gastroenterology & Hepatology and Ailsa Hart St Mark's Hospital and many others

To become a REACH-IBD member once you've completed your medical training, join here. ishortn.ink/ProMembershipx

I am so thrilled that our study defining mechanisms of #PerianalFistula in #Crohns disease is now out in Med by Cell Press . Thank you to Judy Cho + team, Mount Sinai IBD Center MountSinai Pathology SinaiMSTP , and the patients who made this possible
doi.org/10.1016/j.medj…

Stefan Holubar MD MS Miguel Regueiro Cleveland Clinic Benjamin Cohen MD MAS Florian Rieder Scott R. Steele Michael A. Valente Olga Lavryk, MD This sounds super promising! Thank you for the hard work! Hopefully will reduce time to diagnosis and treatment for #pouch concerns and improve overall QoL ultimately. Congrats 👏🏽

Stefan Holubar MD MS doing fantastic work for the care of our pouch patients!!

A recent research effort compared Kono-S anastomosis and stapled side-to-side anastomosis in patients with Crohn's disease: cle.clinic/3UswCop

Bedtime reading 😀 #WeTheFibrosisLab 🔬 #STARConsortium . Stay tuned for more news coming soon… Pranab Mukherjee Jyotsna Chandra, Ph.D. Ren Mao，MD，PhD Idan Goren Miguel Regueiro Stefan Holubar MD MS Katie Falloon Suha Abushamma, MD Joseph Sleiman, MD Taha Qazi David Bruining Sara El Ouali MD Arielle Kanters