New study with Xavier Jeunemaitre, Hadchouel Juliette Gerardo Gamba, María Chávez Canales et al, and our members, @PAWellingMD; Olivier Staub; Rick Grimm reveals KS-WNK1 activates the WNK-SPAK potassium switch pathway stimulates NCC to cause Type IV RTA. jci.org/articles/view/…

“Distal Convoluted Tubule Sexual Dimorphism Revealed by Advanced 3D-Imaging” out in American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…

Leducq team reports sexual dimorphism of the Distal Convoluted Tubule in AJP Renal, and captures the cover.

The LeDucq Network, Potassium in Hypertension, is happy to share a recent publication: Roles of WNK4 and SPAK in K+ mediated dephosphorylation of the sodium chloride cotransporter | American Journal of Physiology-Renal Physiology journals.physiology.org/doi/abs/10.115…

Mide tu presión arterial, contrólala y vive más ! cuida tus riñones #DiaMundialDeLaHipertensionArterial Int Society of Nephrology

Very happy to see this in press - it has been a long road. High dietary potassium causes ubiquitin-dependent degradation of the kidney sodium-chloride cotransporter jbc.org/article/S0021-…

Kortenoeven et al. show that hyperkalemia drives NCC ubiquitylation and degradation via a PP1α-dependent process facilitated by Hsp70 — @SUND_SDU Aarhus Universitet #PTM #hypertension Authors: Marleen Kortenoeven Henrik Dimke Søren Brandt Poulsen Sathish Murali Rob Fenton jbc.org/article/S0021-…

Urinary extracellular vesicles can be isolated from urine and are a stable source of proteins. This study found that proteomic analysis of uEVs in rats reliably reflects protein changes in the kidney bit.ly/j2020071035 @PAWellingMD Rick Grimm Sathish Murali David Ellison

Philip Neustrom J. Brian Byrd Both DASH and the quoted meta analysis show that potassium is most helpful when sodium intake is high. Look at figure 8 in the paper I cited.

#ArticlesInPress: Critical role of the #MineralocorticoidReceptor in aldosterone-dependent and aldosterone-independent regulation of #ENaC in the distal nephron" By: Viatcheslav Nesterov, et al ow.ly/cUah50FxrjT #AJPRenal #aldosterone

The aldosterone to renin ratio (ARR) in 871 Raine Study participants at age 17 and 758 at age 27 had sex-specific associations with BP. The ARR may help to assess hypertension in young people. Jun Yang @marcus_schlaich Michael Stowasser Morag Young ow.ly/Ve1U30rPjFT

Effect of Salt Substitution on Cardiovascular Events and Death | NEJM nejm.org/doi/full/10.10…

Network members, David Ellison and @PAWellingMD, describe a new paradigm of salt physiology in “Insights into Salt Handling and Blood Pressure” | NEJM nejm.org/doi/full/10.10…

Congratulations to our own European Coordinator, Dr. Robert Fenton his award from the American Physiological Society, Renal Section American Physiological Society of the 2022, Carl W. Gottschalk Distinguished Lecturer.

frontiersin.org/article/10.338… Nice study from Mathias Kristensen, Robert Fenton in Søren Brandt Poulsen’s group providing support for the idea that thiazide sensitive renal sodium absorption in primary hyperaldosteronism is driven by hypokalemia rather than aldosterone

Ryan Cornelius, Associate of LeDucq Potassium in Hypertension Network, in David Ellison’s Lab demonstrates that COP9 Signalosome controls the WNK4-NCC Pathway in the distal convoluted tubule, deletion mimics Familial Hyperkalemic Hypertension. FASEB J. 2022 PMID: 35552026.

Congratulations, Xiao-Tong Su, for winning the #EB22 Phys Rep #Renal Section Abstract Award! "Uncovering Distal Convoluted Tubule (DCT) Heterogeneity with Enriched DCT Single-Nucleus RNA Sequencing" Xiaotong Su American Physiological Society The Physiological Society

EDITORS PICK: Eplerenone caused natriuresis and potassium retention in mice lacking aldosterone, indicating that some kidney mineralocorticoid receptors are activated normally by glucocorticoid hormones rather than aldosterone David Ellison HiBP-LeDucq ahajrnls.org/3HFubXN

#COP9 signalosome deletion promotes renal injury and distal convoluted tubule remodeling Ryan J. Cornelius, Jonathan W. Nelson, Xiao-Tong Su, Chao-Ling Yang, and David H. Ellison 👀ow.ly/g2Qz50JT3AT #AJPRenal #JAB1 OHSU News David Ellison Jonathan Nelson (He/Him) Xiaotong Su

Latest paper from HiBP-LeDucq on using uEVs to study the K switch Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter frontiersin.org/articles/10.33…