Exciting RFA opportunity for RET+ lung and RET altered cancers. Please share with those who might be interested! Feb 9 LOI deadline. lungevity.org/news/media-rel… lungevity.org/news/media-rel… LUNGevity Foundation #LCSM Chat RET Renegades

Delighted to launch our first KeyPoints micro-learning for oncologists; this one focused on RET fusion-positive NSCLC. Thanks to Benjamin Besse Mihaela Aldea Gustave Roussy for their expert opinions oncshare.com/ret-fusion-pos…

Don’t miss out! My colleague Tejas Patil presenting his exciting work on early MET bypass signaling in ALK and RET driven NSCLC. He is also an CU Cancer Center Rising Star! LUNGevity Foundation ALK Positive RETpositive #LCSM #AACR24

#Myeloma Paper of the Day: Long-term follow-up of Phase III CASSIOPEIA trial confirms Dara maintenance is superior to observation (HR 0.49; p<0.0001), and now shows that D-VTd + Dara maintenance is better than D-VTd w/o maintenance (HR 0.76; p=0.048): pubmed.ncbi.nlm.nih.gov/38889735/.

Maybe it doesn’t matter how one achieves the deepest responses either 1 or 2 transplants or consolidation/maintenance ??

Absolutely 💯

Congrats 🍾🎊🎉🎈 Nisha Joseph, MD Sagar Lonial MD Ajay Nooka, MD, MPH Emory’s real world experiences further support 4-drugs reg as the new standard for TE pts specifically SR pts. DRVd is for SR&HR. ? MRD data ? MRD conversion rate. Perseus ~50% after consolidation. ? Rate in VR main.

CASSIOPEIA update MRD post consolidation MRD negative superior and PFS follows 72 mos 67%. MRD status mot important 77% (Dara pre/post) 70.7, 70.9 vs 51% (no Dara) negativity. Bottom line, while lots of caveats daratumumab is better > higher MRD negativity #IMS24RF #mmsm

Just out: Results of the CEPHEUS trial presented by Saad Z. Usmani MD MBA FACP 🇺🇸🇵🇰 Memorial Sloan Kettering Cancer Center at the Plenary Session Myeloma Society Significant improvement in PFS with Dara-VRd compared to VRd in patients who were transplant ineligible or deferred. Median age 70. 1/

This is extremely important - DaraRVd benefit standard risk pts more than high risk. Don’t just use anti-CD38 Ab + RVd only in high risk pts. In fact IMO, a better regimen will be needed for high risk pts !

In Perseus (ph III), Griffin (ph 2) DRVd beats RVD. In Benefit, IRVd beats IRd. In IMROZ IRd beats RVD and now in Cepheus DRVd beat RVd. Sure DRVd won but is DRVD much better than DRd? Yes 4 MRD rates & ? PFS/OS though in what magnitude. Hard to beat PFS of 60+ months in DRd.

Dara pre & post - highest rate of MRD -ve. For post consolidation MRD + ve pts, the conversion rate (conR) ~ 50% for DaraR & compared favorably to R alone - Perseus & Auriga. What is the ConR for D alone ? For post con MRD neg pts, R vs D ? D more tolerable for some pt. ? Same.

Dear STEROID/DEXA, you have been one of our BEST friends for decades - tx of MM/NHL, pre-med, GVHD, DAH, allergies, ITP, AIHA, CRS, ICAN etc and more importantly whenever we don’t know what to do, we give steroid 😂 We can’t let you go though probably we are giving too much!!!

Increasing difficulty to find Dara-naive patients. Also do not know what happens to DADA alone vs Rev alone versus Dara R

When your visionary request is not getting the desired results from people in the middle, may be good to take it to the very top. The great Dr. Robert A. Kyle in 1968. From his memoir. #MedTwitter Morie Gertz

Curative intent

For patients with symptomatic multiple myeloma; I think it’s time to have the division of transplant eligible and transplant ineligible formally RETIRE. Stop using it in all circumstances. Pts should be treated based on Frailty . What do u think ?

Defining remission following hematopoietic cell transplant for #myelofibrosis: an international expert panel consensus nature.com/articles/s4137… #MPNsm Leukemia Journal Nico Gagelmann DrDonalMcLornan MPN_Hub The EBMT The EBMT Trainee Committee

🧵 Rituximab-Induced Lung Injury (RILI): A rare but serious complication 🫁 1️⃣ Overview Rituximab is generally safe, but <1% of patients develop lung injury. Onset: within days–weeks of infusion (sometimes delayed). Can occur after any cycle, though early cycles are more

From Barber surgeon to Dr ChatGPT!! Circle of Life !!