People with 2 copies of APOE4 were known to have a high risk of #Alzheimers .
Today that changed to nearly 100% full penetrance
NATURE.med
nature.com/articles/s4159…

The Heidi Jacobs Lab and collaborators have found evidence that changes in the locus coeruleus precede increases of tau proteins in other brain regions. The study used #OpenScience datasets incl. the Allen Human Brain Atlas. massgeneral.org/news/research-…

MassGeneral News Nature Aging

When does Alzheimer’s disease start?
(i.e., their provocative title, not mine)

Recent preprint at Lancet Neurology

The main results of this large-scale analysis across 3 cohorts (n=1,088 w/4,383 Amyloid PET scans):

1⃣ There is a time window of ~16.5 years between crossing the…

All Neuromodulatory Subcortical Systems PIA members have an opportunity to submit their exciting late-breaking science to our PIA day (July 27). Didn't make the AAIC deadline in January? Now is your chance to present your work! Submit your abstract here by May 20: alz.surveymonkey.com/r/H5Z6B85

This is a stellar team! Proud to see that these researchers will continue to build and grow our NSS PIA, to be a platform for early career researchers and create opportunities for networking and collaborating! Congrats to all! 🎉

A 🧵 on our latest manuscript 🎉“Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition”, a collab between Jorge Sepulcre Lab and Heidi Jacobs Lab. #AlzheimerDisease Nature Aging nature.com/articles/s4358…

Happy to share the latest work from Schneider Christoph and Prokopis Prokopiou on the contribution of #locuscoeruleus - MTL functional connectivity to cortical atrophy and cognitive decline! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

In a recent Nature Aging publication, researchers from MGH Martinos Center and colleagues investigated early targeting of the locus coeruleus and how it may delay Alzheimer's progression.

Read more: massgeneral.org/news/research-… @heidijacobslab @sepulcrelab Eli Bueicheku @elouisekoops

Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition nature.com/articles/s4358…

And Eli Bueicheku showed that #locuscoeruleus changes may precede cortical tau, predicting future cognitive decline. She also highlighted some of the genetic features associated with this spatial pattern of tau vulnerability! With Jorge Sepulcre Lab Nature Aging 🎉 nature.com/articles/s4358…

What a great week for our blue spotters team!! Elise Beckers's work on asymmetry in #locuscoeruleus pathology in Alzheimer's Disease was published in Journal of Alzheimer's Disease! 🎉 content.iospress.com/articles/journ…

By insisting that every brain-behavior association study include hundreds or even thousands of participants, we risk stifling innovation. Smaller studies are essential to test new scanning paradigms.

By Emily S. Finn

thetransmitter.org/future-of-fmri…

How to pick a problem. Today in Cell. 1/53
cell.com/cell/fulltext/…

Researchers from @mghimaging and colleagues find that greater social activity can provide resilience against Alzheimer’s disease pathology and cognitive decline, in a @MolPsychiatry study. doi.org/10.1038/s41380…

Excited to share this review on one of my favorite biological problems:

Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms.

Out in Nature Rev Neurosci today!

nature.com/articles/s4158…

📢 Calling all ISTAART members! Shape the future of your Professional Interest Areas (PIAs) by participating in the 2024 PIA Elections.

Cast your vote today and have your say in the leadership of your PIA! 🗳️🌟

Vote now at alz.surveymonkey.com/r/2024PIAelect

The Martinos Center is seeking postdoctoral candidates for the MARTINOS FELLOWSHIP PROGRAM! Learn more and apply here: bit.ly/49YKQD2

Midnight in Boston, but worth it: Excellent seminar on the multiple views of the human brainstem catecholamine neurons at Sydney University!

To all the fellow #locuscoeruleus enthusiasts! We are thrilled to announce a new LC meeting! This year focusing in particular on sleep and subcortical atlases, with contributions from Weinshenker Lab Heidi Jacobs Lab Cambridge FTD and many more excellent researchers!

Starting in 30 minutes!! 👇 Come and join us! Neuromodulatory Subcortical Systems PIA