Another great contribution from Harvard Med Cell Bio faculty member Lucas Farnung

Accelerated proteome-wide identification of reactive Cys residues from the Gygi Lab and Qing Yu driven by Ka Yang !!

New work from Rapoport Lab Harvard Med Cell Bio identifies a new class of highly curved vesicles containing REEP1 class of reticulon homology domain proteins biorxiv.org/content/10.110…

New work from Harvard Med Cell Bio faculty Adrian Salic defines new extracellular carriers of lipid modified WNTs and the underlying mechanism transfer to FZD receptors!!

New exciting work from Harvard Med Cell Bio faculty Kirchhausen lab identified endosomal perforations as a key feature in creation of synuclein aggregates in neurons. biorxiv.org/content/10.110…

Another super cool paper from Harvard Med Cell Bio faculty member Susan Shao describes a small molecule degrader for a translational termination factor!

Congratulations to Harvard Med Cell Bio faculty member Ed Chouchani Ed Chouchani on receiving a Marks Foundation Emerging Leader Award! So well deserved.

Ever wonder how molecular machines are made? Now Frank Adolf ❄️🔬🧬 & Jiale Du in Brenda Schulman lab Max Planck Institute of Biochemistry (MPIB) , John Hanna (BWH/Harvard), & Wade Harper Harvard Med Cell Bio use cryo-EM to visualize chaperone-mediated stepwise assembly of the 20S proteasome biorxiv.org/content/10.110…

New work from Ann Hochschild Harvard Micro and Wade Harper & Joao Paulo Harvard Med Cell Bio develop "translational tiling proteomics" as an unbiased way to identify non-programmed translational frameshifting by bacterial ribosomes in cells and in vitro. pnas.org/doi/10.1073/pn…

It is with great sadness that we announce the passing of our colleague & friend Professor Dan Goodenough (Takeda Professor of Cell Biology emeritus, Harvard Med Cell Bio ), a pioneer in the study of gap junctions, an acclaimed educator & activist for change. ascb.org/member-news/in…

ER remodelling by ER-phagy in neurogenesis | Nature Cell Biology. Amazing work by ⁦Melissa Hoyer⁩ ⁦Florian Wilfling⁩ ⁦The Wilfling Lab⁩ ⁦Wade Harper⁩ ⁦Harvard Med Cell Bio⁩ nature.com/articles/s4155…

ER remodeling during neurogenesis by autophagy & visualization of ER cargo capture in axons by cryo-ET Melissa Hoyer Wade Harper Harvard Med Cell Bio Cristina Capitanio Anna Bieber Brenda Schulman lab Max Planck Institute of Biochemistry (MPIB) & Florian Wilfling Max Planck Institute of Biophysics Aligning Science Across Parkinson’s nature.com/articles/s4155…

CONGRATULATIONS!! to Harvard Med Cell Bio faculty member David Pellman for receiving the AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research. So well deserved!! aacr.org/about-the-aacr…

New work from the Liberles Lab Harvard Med Cell Bio reveal a role for Piezo2 expressed in lung epithelial cells of the neuroepithelial body in a neuronal reflex of the vagus nerve evoked by airway closure that leads to gasping. nature.com/articles/s4158…

So happy for our own Harvard Med Cell Bio faculty member David Pellman on being awarded the Clowes Award for Outstanding Basic Cancer Research by the AACR. His work on chromosome instability has been transformational!

Molecular machines rule! Frank Adolf ❄️🔬🧬 & Jiale Du in Brenda Schulman lab Max Planck Institute of Biochemistry (MPIB) , John Hanna (BWH/Harvard), & Ellen Goodall Wade Harper Harvard Med Cell Bio visualize chaperone-mediated stepwise assembly of the 20S proteasome by cryo-EM Aligning Science Across Parkinson’s nature.com/articles/s4159…

Cool paper from our neighbors Johannes Walter and Ernst Schmid in Harvard Med BCMP describes a new classifier for improving alphafold-based interaction screening. biorxiv.org/content/10.110…

New work on the kinetics of protein turnover - this was one of the last projects from our own Fred Goldberg! Thanks to the Knowles lab KnowlesLab Cambridge and Galen Collins making this a reality. pnas.org/doi/10.1073/pn…

As usual, lots to think about from Harvard Med Cell Bio 's Gygi Lab presentations at ASMS!

CONGRATULATIONS ! to Harvard Med Cell Bio faculty Susan Shao and Ed Chouchani, who were both named HHMI investigators! So well deserved and we look forward to all of the exciting science to come! hhmi.org/news/hhmi-inve…