Catastrophic risks facing humanity include #nuclearweapons #pandemics #AI & #climatechange. Leading experts discuss ways to measure & mitigate the risks. Stanford Existential Risks Initiative Conference 4/17 – 18. Rose Gottemoeller @AVastMachine Toby Ord sericonference.org

Happy to share our work on dual-use considerations of biomedical research in the wake of COVID-19. It was a pleasure working with this incredible team! Jonas Sandbrink Joshua Teperowski Monrad @meganjpalmer Gregory Koblentz (now at gregkoblentz.bsky.social).

Ferritin-based protein #vaccines against many viruses are underway, but purification of these particles is challenging. Kim & colleagues Stanford University Sarafan ChEM-H Stanford Biochemistry Chan Zuckerberg Biohub Network now identify sites for polyHis tags, simplifying production. pubs.acs.org/doi/10.1021/ac…

A year ago we asked “what if we could eliminate viruses as current and future health threats?” Today we're thrilled to announce the performer teams to develop a computational model to design vaccines that target many viruses at once for our APECx program! arpa-h.gov/news-and-event…

absolutely incredible

happy to have helped review a white paper detailing the risks of creating mirror life. mirror bacteriophage are not far away...

Many of the most complex and useful functions in biology emerge at the scale of whole genomes. Today, we share our preprint “Generative design of novel bacteriophages with genome language models”, where we validate the first, functional AI-generated genomes 🧵

How do protein language models (PLM) think about proteins?🧬 We answer this w/ #InterPLM, just published in Nature Methods! Using sparse autoencoders + LLM agent, we identify 1000s of interpretable concepts learned by PLMs, pointing to new biology 🧵

Saying this again Line between chronic disease & infectious disease is artificial HPV causes cervical cancer Increasingly looks like EBV may cause Multiple Sclerosis or even Lupus We need to refocus on new vaccines to prevent or even treat many chronic diseases