🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Exciting new work from our lab describing a novel platform for MHC-II recognition, called TRACeR, that uses just a single loop! Congratulation to Haotian Du, Jingjia Liu, and the team biorxiv.org/content/10.110…

Our sequel review paper titled “Sparks of function by de novo protein design” is now out in Nature Biotechnology! Alex Chu Tianyu Lu Full-access link here: rdcu.be/dyJue

Had fun putting together this review! Lots of good surveys of the literature lately so mostly we used it as a chance to look carefully at the key impacts on de novo design, and sneak a few hot/cold(?) takes. Also we figured out a way to reference elephants 🐘 in the text 😂

Following our field's inspiring history of building synthetic receptors, here we share our lab's first attempt at a post-transcriptional one. Based on ADAR-editing and compatible with various inputs/outputs.

Our all-atom generative model is out now in PNASNews! Check out the lab github for the most up-to-date models and methods. Congrats to the whole team: Alex Chu, Jinho Kim, Lucy, Gina El Nesr, Minkai Xu, Richard Shuai.

Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with Possu Huang Lab. By recognizing diverse #MHC-I antigens (cancer, autoimmune & pathogenic), we're paving the way for more accessible immunotherapies. Congratulations to

A general system for targeting MHC class II–antigen complex via a single adaptable loop go.nature.com/4gj5OQk

Targeting peptide antigens using a multiallelic MHC I-binding system go.nature.com/4gcLzn5

New online in Nature Biotechnology: Specific binders to peptide-MHC class II are rapidly generated without laborious screening, by Haotian Du Jingjia Liu et al. Possu Huang Lab

Another work from Possu Huang Lab by Haotian Du et al. : A protein platform rapidly develops peptide-focused MHC class I binders with high specificity.

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens TRACeR for MHC-I: go.nature.com/4gcLzn5 TRACeR for MHC-II: go.nature.com/4gj5OQk Haotian Du Jingjia Liu SgourakisLab Stanford Biosciences Penn Allergy and Immunology CHOP Research

Excited to share that TRACeR stories are out🙌

A synthetic scaffold to target peptide–MHC complexes #NBTNV go.nature.com/3ZFVH0O

Thanks Michael Birnbaum and lab for the great perspective on TRACeR papers!

Excited to share my latest first-author manuscript, now available as a preprint on bioRxiv Immunology! We introduce VLP-Open HLA, a new protein-based nanoparticle platform for T-cell screening studies, leveraging SpyTag/SpyCatcher bioconjugation chemistry and engineered open MHC-I!

New preprint from our group! We propose SHAPES, a set of metrics to quantify the distributional coverage of generative models of protein structures with embeddings at different structural hierarchies and quantify undersampling / extrapolation behaviors.

Congrats🤩 Gina El Nesr